| Drug Name |
Doxycycline hyclate |
| Drug ID |
BADD_D00727 |
| Description |
Doxycycline is a broad-spectrum antibiotic synthetically derived from oxytetracycline [FDA label]. This drug is a second-generation tetracycline, exhibiting lesser toxicity than first-generation tetracyclines [A174034]. Doxycycline may be used to treat a wide range of bacterial infections, depending on the results of antibiotic susceptibility testing. |
| Indications and Usage |
Doxycycline is indicated for the treatment of various infections by gram-positive and gram-negative bacteria, aerobes and anaerobes, as well other types of bacteria. A complete list of organisms is available in the FDA label and in the "indications" section of this drug entry [FDA label].
The following are some of the major infections that may be treated with doxycycline [FDA label]:
Rocky mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsialpox, and tick fevers caused by Rickettsiae
Respiratory tract infections caused by Mycoplasma pneumoniae
Lymphogranuloma venereum caused by Chlamydia trachomatis
Psittacosis (ornithosis) caused by Chlamydia psittaci
Trachoma caused by Chlamydia trachomatis, although the infectious agent is not always eliminated as judged by immunofluorescence
Inclusion conjunctivitis caused by Chlamydia trachomatis
Uncomplicated urethral, endocervical or rectal infections in adults caused by Chlamydia trachomatis
Nongonococcal urethritis caused by Ureaplasma urealyticum
Relapsing fever due to Borrelia recurrentis
**A note regarding anti-microbial resistance**
It is important to note that doxycycline is not the drug of choice in the treatment of any type of staphylococcal infection.
Up to 44 percent of strains of Streptococcus pyogenes and 74 percent of Streptococcus faecalis have been found to be resistant to tetracyclines. Therefore, tetracyclines such as doxycycline should not be used to treat streptococcal infections unless the microorganism has been demonstrated to be susceptible [FDA label]. |
| Marketing Status |
approved; investigational; vet_approved |
| ATC Code |
A01AB22; J01AA02 |
| DrugBank ID |
DB00254
|
| KEGG ID |
D02129
|
| MeSH ID |
D004318
|
| PubChem ID |
54705095
|
| TTD Drug ID |
D0S0LZ
|
| NDC Product Code |
72789-319; 83112-985; 51552-0852; 71052-030; 27241-154; 0143-9803; 50090-4981; 50090-6134; 51862-557; 51862-709; 53489-118; 55289-502; 62135-596; 62135-626; 63739-168; 67296-1743; 68308-716; 70518-3135; 70518-3213; 70518-3363; 71205-554; 72789-298; 0904-0428; 82982-048; 0069-0950; 51473-0501; 71057-3440; 46708-484; 62135-625; 62332-362; 67296-1811; 67405-550; 68071-5232; 69668-515; 70518-3695; 71205-653; 0591-4550; 0591-5553; 11014-0091; 62991-2572; 67698-101; 23155-611; 0143-3142; 43063-999; 43547-462; 46708-499; 50268-279; 60760-651; 61919-082; 62135-985; 62332-388; 68071-2787; 68999-984; 70771-1104; 70771-1588; 70934-810; 71335-1549; 71335-2086; 60219-2132; 60429-069; 60760-215; 62332-363; 62332-484; 69263-501; 70518-3214; 70934-187; 70934-987; 70934-995; 0591-4575; 72143-211; 72789-277; 80425-0114; 80425-0211; 50546-560; 24658-312; 27241-140; 0143-2112; 45865-116; 46708-481; 46708-482; 50090-5380; 53489-120; 55154-7128; 55289-866; 62332-387; 63187-818; 63187-845; 68047-714; 68071-5265; 68788-7638; 71205-156; 71205-697; 71335-1464; 72578-054; 0904-0430; 27241-153; 40032-794; 42806-312; 50090-5825; 51407-298; 51862-695; 59115-123; 60505-4384; 62332-482; 68071-2777; 68071-3466; 68071-4950; 68788-8217; 70518-1627; 70934-951; 71205-518; 71335-1686; 71610-117; 80425-0280; 51927-0130; 60592-201; 27808-234; 42708-173; 43063-988; 43547-325; 46708-388; 50090-6212; 60687-513; 60760-626; 62135-623; 62332-352; 62332-353; 62332-481; 62332-483; 62332-499; 63187-942; 67296-1801; 68071-4836; 68382-708; 68788-8464; 71335-1768; 72189-127; 72578-001; 72789-276; 82982-060; 10695-103; 50909-8105; 55488-0100; 23155-141; 23155-143; 0143-3141; 50090-6036; 50090-6133; 51655-998; 51862-558; 53489-119; 67296-1456; 68071-5259; 68308-715; 68382-222; 68382-710; 68999-625; 68999-626; 68999-985; 70771-1358; 70771-1359; 70771-1589; 71335-2179; 71335-9718; 72578-055; 82982-053; 51552-1577; 51927-3129; 46708-352; 46708-387; 50090-4867; 50090-5560; 50268-278; 51655-478; 51862-696; 53489-647; 55154-8079; 55700-732; 60505-4382; 62135-984; 62584-693; 68308-775; 68382-221; 69489-111; 70518-3039; 71335-2113; 72789-309; 76420-044; 11014-0090; 11014-0235; 38779-0434; 59929-344; 23155-142; 27241-141; 43386-794; 0143-9802; 43547-324; 45865-444; 46708-483; 50268-277; 53002-2711; 68382-709; 70518-1248; 70518-3706; 70771-1587; 71335-1316; 47621-018; 55018-151; 16110-601; 42192-501; 42806-362; 46708-353; 50090-0023; 50090-5588; 51862-559; 51862-560; 51862-571 |
| UNII |
19XTS3T51U
|
| Synonyms |
Doxycycline | Doxycycline Monohydrate | Vibramycin | Atridox | Doxycycline Phosphate (1:1) | BMY-28689 | BMY 28689 | BMY28689 | BU-3839T | BU 3839T | BU3839T | Doryx | Doxycycline Calcium Salt (1:2) | Doxycycline Hyclate | Doxycycline Hemiethanolate | Doxycycline Monohydrochloride, 6-epimer | Doxycycline Monohydrochloride, 6 epimer | Doxycycline Monohydrochloride, Dihydrate | Doxycycline Calcium | 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S-(4alpha,4aalpha,5alpha,5aalpha,6alpha,12aalpha))- | Alpha-6-Deoxyoxytetracycline | Alpha 6 Deoxyoxytetracycline | Doxycycline-Chinoin | Doxycycline Chinoin | Hydramycin | Oracea | Periostat | Vibra-Tabs | Vibra Tabs | Vibramycin Novum | Vibravenos |
