Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ephedrine
Drug ID BADD_D00777
Description Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with [pseudoephedrine].[A193698] Ephedrine is an adrenergic receptor agonist used for its vasoconstrictive, positive chronotropic, and positive inotropic effects.[L12972] Ephedrine and [phenylephrine] are still commonly used to treat hypotension but their use in other indications has decreased due to the development of more selective adrenergic agonists.[A193701,A193704,L12975] Ephedrine was granted a type 7 FDA Approval on 29 April 2016.[L12975]
Indications and Usage Ephedrine intravenous injections are indicated to treat hypotension under anesthesia,[L12972,L34645] ephedrine injections by multiple routes are indicated to treat allergic conditions such as bronchial asthma,[L12996] ephedrine nasal spray is and OTC medication used as a decongestant.[L12993]
Marketing Status approved
ATC Code C01CA26; R01AA03; R01AB05; R03CA02; S01FB02
DrugBank ID DB01364
KEGG ID D00124
MeSH ID D004809
PubChem ID 9294
TTD Drug ID D0LG8E
NDC Product Code 57218-151
UNII GN83C131XS
Synonyms Ephedrine | Erythro Isomer of Ephedrine | Ephedrine Erythro Isomer | Sal-Phedrine | Sal Phedrine | SalPhedrine | Ephedrine Sulfate | Sulfate, Ephedrine | Ephedrine Hydrochloride | Hydrochloride, Ephedrine | Ephedrine Renaudin | Renaudin, Ephedrine
Chemical Information
Molecular Formula C10H15NO
CAS Registry Number 299-42-3
SMILES CC(C(C1=CC=CC=C1)O)NC
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Agitation19.06.02.001; 17.02.05.012--
Angina pectoris24.04.04.002; 02.02.02.002--
Anxiety19.06.02.002--
Arrhythmia02.03.02.001--Not Available
Asthenia08.01.01.001--Not Available
Benign prostatic hyperplasia21.04.02.001--Not Available
Blood pressure increased13.14.03.005--Not Available
Body temperature increased13.15.01.001--Not Available
Bradycardia02.03.02.002--Not Available
Cardiovascular disorder02.11.01.010; 24.03.02.009--Not Available
Cerebral haemorrhage24.07.04.001; 17.08.01.003--Not Available
Chest pain22.12.02.003; 08.01.08.002; 02.02.02.011--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Delirium19.13.02.001--
Dependence19.07.06.008--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.11.04.006--
Dyspepsia07.01.02.001--
Dyspnoea02.11.05.003; 22.02.01.004--
Dysuria20.02.02.002--
Euphoric mood19.04.02.006--
Extrasystoles02.03.02.003--Not Available
Feeling abnormal08.01.09.014--Not Available
Hallucination19.10.04.003--
Headache17.14.01.001--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypertension24.08.02.001--
Hypotension24.06.03.002--
Insomnia19.02.01.002; 17.15.03.002--
Irritability19.04.02.013; 08.01.03.011--
Muscle spasms15.05.03.004--
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