Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Epoprostenol
Drug ID BADD_D00788
Description A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension.
Indications and Usage For the long-term intravenous treatment of primary pulmonary hypertension and pulmonary hypertension associated with the scleroderma spectrum of disease in NYHA Class III and Class IV patients who do not respond adequately to conventional therapy.
Marketing Status approved
ATC Code B01AC09
DrugBank ID DB01240
KEGG ID D00106
MeSH ID D011464
PubChem ID 5282411
TTD Drug ID D0V0IX
NDC Product Code 66215-402; 62756-060; 66215-403; 62287-123; 62756-059
UNII DCR9Z582X0
Synonyms Epoprostenol | Epoprostanol | Prostaglandin I2 | Prostacyclin | Prostaglandin I(2) | Veletri | Epoprostenol Sodium | Epoprostenol Sodium Salt, (5Z,9alpha,11alpha,13E,15S)-Isomer | Flolan
Chemical Information
Molecular Formula C20H32O5
CAS Registry Number 35121-78-9
SMILES CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)O2)O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Acute coronary syndrome24.04.04.011; 02.02.02.015--Not Available
Haemodynamic instability24.03.02.0060.000288%Not Available
Ear discomfort04.03.01.0050.000181%Not Available
Catheter site erythema23.03.06.014; 12.07.02.003; 08.02.02.0030.002936%Not Available
Catheter site inflammation12.07.02.010; 08.02.02.0100.001250%Not Available
Catheter site pain12.07.02.004; 08.02.02.0040.001735%Not Available
Lymphatic disorder01.09.01.003--Not Available
Paranasal sinus discomfort22.12.03.0180.000362%Not Available
Musculoskeletal discomfort15.03.04.0010.000082%Not Available
Secretion discharge08.01.03.0190.000164%Not Available
Infusion site pain12.07.05.002; 08.02.05.0140.000164%Not Available
Infusion site swelling12.07.05.003; 08.02.05.0020.000082%Not Available
Foetal death18.01.02.003; 08.04.01.0110.000082%
Haemorrhage24.07.01.0020.001110%Not Available
Pulmonary mass22.02.07.0040.000082%Not Available
Procedural complication12.02.05.005--
Major depression19.15.01.003--Not Available
Toxic skin eruption12.03.01.073; 23.03.05.003; 10.01.01.0080.000082%Not Available
Vasodilation procedure25.03.01.001--Not Available
Thyroid mass05.02.01.0030.000222%Not Available
Restless legs syndrome15.05.03.012; 17.02.07.0080.000181%Not Available
Angiopathy24.03.02.007--Not Available
Hot flush08.01.03.027; 24.03.01.005; 21.02.02.0010.000304%
Adverse event08.06.01.0100.000551%Not Available
Abdominal hernia07.16.06.0050.000164%Not Available
Appetite disorder14.03.01.004; 19.09.01.0020.000123%Not Available
Cardiac disorder02.11.01.0030.000617%Not Available
Connective tissue disorder10.04.04.026; 15.06.01.006--Not Available
Feeding disorder19.09.01.003; 14.03.02.0030.000082%Not Available
Embolism24.01.01.0090.000123%
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