Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Epoprostenol
Drug ID BADD_D00788
Description A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension.
Indications and Usage For the long-term intravenous treatment of primary pulmonary hypertension and pulmonary hypertension associated with the scleroderma spectrum of disease in NYHA Class III and Class IV patients who do not respond adequately to conventional therapy.
Marketing Status approved
ATC Code B01AC09
DrugBank ID DB01240
KEGG ID D00106
MeSH ID D011464
PubChem ID 5282411
TTD Drug ID D0V0IX
NDC Product Code 66215-402; 62756-060; 66215-403; 62287-123; 62756-059
UNII DCR9Z582X0
Synonyms Epoprostenol | Epoprostanol | Prostaglandin I2 | Prostacyclin | Prostaglandin I(2) | Veletri | Epoprostenol Sodium | Epoprostenol Sodium Salt, (5Z,9alpha,11alpha,13E,15S)-Isomer | Flolan
Chemical Information
Molecular Formula C20H32O5
CAS Registry Number 35121-78-9
SMILES CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)O2)O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Blister23.03.01.001; 12.01.06.0020.000584%Not Available
Body temperature increased13.15.01.001--Not Available
Bone pain15.02.01.0010.000403%
Bradycardia02.03.02.002--Not Available
Bronchospasm22.03.01.004; 10.01.03.0120.000263%
Burning sensation17.02.06.001; 08.01.09.0290.000288%Not Available
Cardiac arrest02.03.04.0010.000781%
Cardiac failure02.05.01.0010.001357%
Cardiac failure acute02.05.01.0050.000082%Not Available
Cardiac failure congestive02.05.01.0020.000987%Not Available
Cardiac failure high output02.05.01.0100.000123%Not Available
Cardiac tamponade02.06.01.0010.000082%
Cardio-respiratory arrest22.02.06.007; 02.03.04.0020.000329%Not Available
Cardiogenic shock24.06.02.006; 02.05.01.0030.000247%Not Available
Cardiomegaly02.04.02.0010.000164%Not Available
Catheter site related reaction12.07.02.001; 08.02.02.0010.000263%Not Available
Cellulitis23.11.02.004; 11.02.01.001--Not Available
Chest discomfort22.12.02.002; 08.01.08.019; 02.02.02.0090.001036%Not Available
Chest pain22.12.02.003; 08.01.08.002; 02.02.02.0110.003726%Not Available
Chills15.05.03.016; 08.01.09.0010.001094%
Cholangitis09.02.01.0020.000082%Not Available
Cholecystitis09.03.01.0010.000123%
Cholelithiasis09.03.01.0020.000164%Not Available
Chronic obstructive pulmonary disease22.03.01.0070.000288%Not Available
Circulatory collapse24.06.02.0010.000123%Not Available
Coagulopathy01.01.02.0010.000082%Not Available
Cold sweat23.02.03.002; 08.01.03.0240.000181%Not Available
Collagen disorder15.06.01.005; 10.04.04.002--Not Available
Colon cancer07.21.01.001; 16.13.01.0010.000123%Not Available
Condition aggravated08.01.03.0040.002624%Not Available
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