Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ertapenem sodium
Drug ID BADD_D00803
Description Ertapenem is a carbapenem antibiotic drug that is marketed under the trade name Invanz by Merck & Co. pharmaceutical company. It is structurally similar to [meropenem] and possesses a 1-beta-methyl group.
Indications and Usage For the treatment the following moderate to severe infections caused by susceptible isolates of the designated microorganisms: (1) complicated intra-abdominal infections due to Escherichia coli, Clostridium clostridioforme, Eubacterium lentum, Peptostreptococcus species, Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, or Bacteroides uniformis, (2) complicated skin and skin structure infections, including diabetic foot infections without osteomyelitis due to Staphylococcus aureus (methicillin susceptible isolates only), Streptococcus agalactiae, Streptococcus pyogenes, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Bacteroides fragilis, Peptostreptococcus species, Porphyromonas asaccharolytica, or Prevotella bivia, (3) community acquired pneumonia due to Streptococcus pneumoniae (penicillin susceptible isolates only) including cases with concurrent bacteremia, Haemophilus influenzae (beta-lactamase negative isolates only), or Moraxella catarrhalis, (4) complicated urinary tract infections including pyelonephritis due to Escherichia coli, including cases with concurrent bacteremia, or Klebsiella pneumoniae, (5) acute pelvic infections including postpartum endomyometritis, septic abortion and post surgical gynecologic infections due to Streptococcus agalactiae, Escherichia coli, Bacteroides fragilis, Porphyromonas asaccharolytica, Peptostreptococcus species, or Prevotella bivia.
Marketing Status approved; investigational
ATC Code J01DH03
DrugBank ID DB00303
KEGG ID D04049
MeSH ID D000077727
PubChem ID 23674512
TTD Drug ID D0Q1MS
NDC Product Code 42023-221; 72266-159; 0143-9398; 0006-3843; 44647-051; 69806-0003; 60505-6196; 68001-408; 63323-823; 68083-351; 59651-190
UNII 2T90KE67L0
Synonyms Ertapenem | Invanoz | Invanz | Ertapenem Sodium
Chemical Information
Molecular Formula C22H24N3NaO7S
CAS Registry Number 153773-82-1
SMILES CC1C2C(C(=O)N2C(=C1SC3CC(NC3)C(=O)NC4=CC=CC(=C4)C(=O)[O-])C(=O)O)C(C)O.[Na+]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Gait disturbance15.03.05.013; 17.02.05.016; 08.01.02.002--
Gastritis07.08.02.001--
Gastrooesophageal reflux disease07.02.02.003--
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.001--Not Available
Genital rash23.03.13.016; 21.10.01.009--Not Available
Gout15.01.06.001; 14.09.01.001--Not Available
Haematochezia24.07.02.012; 07.12.02.003--Not Available
Haematocrit decreased13.01.05.001--Not Available
Haematoma24.07.01.001--
Haematuria24.07.01.047; 20.02.01.006; 21.10.01.018--
Haemoglobin decreased13.01.05.003--Not Available
Haemoptysis02.11.04.009; 24.07.01.006; 22.02.03.004--Not Available
Haemorrhoids24.10.02.002; 07.15.03.001--
Hallucination19.10.04.003--
Headache17.14.01.001--
Herpes simplex23.11.05.004; 11.05.02.001--Not Available
Hiccups22.12.01.001; 07.01.06.009--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypertension24.08.02.001--
Hypoaesthesia23.03.03.081; 17.02.06.023--Not Available
Hypotension24.06.03.002--
Hypothermia12.05.03.001; 08.05.01.003--
Hypoxia22.02.02.003--
Ileus07.13.01.001--
Injection site induration12.07.03.007; 08.02.03.007--Not Available
Injection site pain12.07.03.011; 08.02.03.010--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Intestinal obstruction07.13.01.002--Not Available
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.004--Not Available
Lung infiltration22.01.02.004--Not Available
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