Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Estramustine phosphate
Drug ID BADD_D00827
Description A nitrogen mustard linked to estradiol, usually as phosphate; used to treat prostatic neoplasms; also has radiation protective properties.
Indications and Usage Not Available
Marketing Status approved; investigational
ATC Code L01XX11
DrugBank ID DB14674
KEGG ID D02398; D06397; D04066
MeSH ID D004961
PubChem ID 259329
TTD Drug ID D03SRY
NDC Product Code Not Available
UNII MUZ9585Y7B
Synonyms Estramustine | Estracyt | Estramustine Phosphate Sodium | Phosphate Sodium, Estramustine | Leo-275 | Leo 275 | Leo275 | NSC-89199 | NSC 89199 | NSC89199 | Emcyt | Estramustinphosphate | Estramustin Phosphate | Phosphate, Estramustin
Chemical Information
Molecular Formula C23H32Cl2NO6P
CAS Registry Number 4891-15-0
SMILES CC12CCC3C(C1CCC2OP(=O)(O)O)CCC4=C3C=CC(=C4)OC(=O)N(CCCl)CCCl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Anaemia01.03.02.001--
Angioedema22.04.02.008; 23.04.01.001; 10.01.05.009--Not Available
Cardiac failure congestive02.05.01.002--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.001--
Dyspepsia07.01.02.001--
Embolism venous24.01.01.003--Not Available
Feeling abnormal08.01.09.014--Not Available
Fluid retention14.05.06.002; 20.01.02.003--Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Gynaecomastia21.05.04.003; 05.05.02.003--
Headache17.14.01.001--
Hypertension24.08.02.001--
Lethargy17.02.04.003; 08.01.01.008; 19.04.04.004--
Leukopenia01.02.02.001--Not Available
Libido decreased21.03.02.005; 19.08.03.001--
Muscular weakness15.05.06.001; 17.05.03.005--
Myocardial infarction24.04.04.009; 02.02.02.007--
Myocardial ischaemia24.04.04.010; 02.02.02.008--Not Available
Nausea07.01.07.001--
Oedema14.05.06.010; 08.01.07.006--Not Available
Polyuria20.02.03.002--Not Available
Rash23.03.13.001--Not Available
Thrombocytopenia01.08.01.002--Not Available
Vomiting07.01.07.003--
Acute coronary syndrome02.02.02.015; 24.04.04.011--Not Available
Transaminases increased13.03.04.036--Not Available
Disturbance in sexual arousal19.08.04.003--Not Available
Embolism24.01.01.009--
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