Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Eszopiclone
Drug ID BADD_D00837
Description Eszopiclone, marketed by Sepracor under the brand-name Lunesta, is a nonbenzodiazepine hypnotic drug used to treat insomnia. It is the active stereoisomer of zopiclone, belonging to the class of drugs known as _cyclopyrrolones_.[A179638,L6850] Cyclopyrrolone drugs demonstrate high efficacy and low toxicity[A179827], offering a safer alternative to other drugs used for insomnia. One major benefit of eszopiclone is that it is approved by the FDA for the long-term treatment of insomnia. This sets it apart from many other hypnotic sedatives, which are generally approved only for the relief of short-term (6-8 weeks) insomnia. Eszopiclone was initially approved by the FDA in 2004.[L6769]
Indications and Usage Eszopiclone is indicated for the treatment of insomnia.[L6769]
Marketing Status approved; investigational
ATC Code N05CF04
DrugBank ID DB00402
KEGG ID D02624
MeSH ID D000069582
PubChem ID 969472
TTD Drug ID D06ZII
NDC Product Code 80425-0067; 66039-847; 42043-320; 45865-829; 55700-581; 60760-511; 61919-033; 63187-970; 63402-191; 0378-5270; 65862-967; 65862-968; 68788-8387; 69452-348; 71205-384; 80425-0098; 55111-878; 63278-1059; 64330-044; 66022-0106; 43063-795; 47335-587; 60760-325; 63187-665; 68180-324; 68788-8077; 69452-347; 71205-633; 71335-0116; 71335-0148; 72189-099; 80425-0065; 66639-019; 33342-300; 50090-4202; 50436-3384; 0378-5272; 65862-969; 71205-236; 55111-629; 60429-633; 70518-1310; 70518-2979; 71205-581; 63285-831; 50090-3514; 55700-610; 60429-632; 60760-526; 61919-395; 63187-579; 63402-193; 63629-5319; 68462-382; 68788-7667; 71335-0005; 71335-0089; 80425-0062; 72761-013; 0093-5537; 50436-3383; 55700-621; 63187-817; 63402-190; 68462-383; 68788-7169; 71335-1662; 72789-067; 80425-0064; 80425-0168; 63285-830; 63285-832; 0093-5539; 33342-301; 43353-101; 47335-588; 55111-617; 61919-119; 68180-322; 68462-384; 71335-0574; 76420-026; 80425-0063; 0093-5538; 33342-299; 43353-097; 45865-828; 55111-619; 61919-991; 69452-349; 71335-2002; 71610-409; 42043-321; 42043-322; 45865-830; 47335-586; 63187-843; 0378-5271; 68180-323; 68788-7029; 71335-0512; 71335-0598; 71335-1794; 80425-0115; 60429-634; 70518-0815; 70518-3395; 70518-3576; 71205-513; 71335-9659; 76420-024; 76420-027; 80425-0066; 11722-057
UNII UZX80K71OE
Synonyms Eszopiclone | Lunesta | Estorra
Chemical Information
Molecular Formula C17H17ClN6O3
CAS Registry Number 138729-47-2
SMILES CN1CCN(CC1)C(=O)OC2C3=NC=CN=C3C(=O)N2C4=NC=C(C=C4)Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Abnormal dreams19.02.03.001; 17.15.02.001--Not Available
Acne23.02.01.001--Not Available
Aggression19.05.01.0010.000594%Not Available
Agitation19.06.02.001; 17.02.05.0120.001123%
Alopecia23.02.02.001--
Altered state of consciousness19.07.01.003; 17.02.04.0010.000550%Not Available
Amenorrhoea21.01.02.001; 05.05.01.002--
Amnesia19.20.01.001; 17.03.02.0010.000594%
Anaemia01.03.02.001--
Anaphylactic shock24.06.02.004; 10.01.07.0020.000220%Not Available
Anterograde amnesia19.20.01.005; 17.03.02.0050.000330%Not Available
Anxiety19.06.02.0020.000814%
Apathy19.04.04.002--Not Available
Arthritis15.01.01.001--
Arthropathy15.01.01.003--Not Available
Asthenia08.01.01.001--Not Available
Asthma10.01.03.010; 22.03.01.002--Not Available
Ataxia17.02.02.001; 08.01.02.004--
Back pain15.03.04.0050.000220%
Bladder pain20.02.02.001--Not Available
Body temperature increased13.15.01.001--Not Available
Breast engorgement21.05.05.002; 18.08.02.001--Not Available
Breast enlargement21.05.04.001--Not Available
Breast neoplasm21.05.01.004; 16.10.02.001--Not Available
Breast pain21.05.05.003--
Breath odour07.01.06.002--Not Available
Bronchitis22.07.01.001; 11.01.09.001--
Bursitis12.04.03.010; 15.04.01.001--Not Available
Cardiac arrest02.03.04.0010.000220%
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