Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ethambutol
Drug ID BADD_D00841
Description Ethambutol is a bacteriostatic agent indicated alongside medications such as [isoniazid], [rifampin], and [pyrazinamide] in the treatment of pulmonary tuberculosis.[L31743] Ethambutol was first described in the literature in 1961.[A229048] It was developed out of a need for therapies active against isoniazid resistant strains of _Mycobacterium tuberculosis_.[A229048] Ethambutol was granted FDA approval on 6 November 1967.[L31663]
Indications and Usage Ethambutol is indicated in combination with other anti-tuberculosis drugs in the treatment of pulmonary tuberculosis.[L31663] Ethambutol is commonly used in combination with [isoniazid], [rifampin], and [pyrazinamide].[L31743]
Marketing Status approved
ATC Code J04AK02
DrugBank ID DB00330
KEGG ID D07925
MeSH ID D004977
PubChem ID 14052
TTD Drug ID D08QME
NDC Product Code 60592-243
UNII 8G167061QZ
Synonyms Ethambutol | Dexambutol | Etibi | EMB-Fatol | EMB Fatol | Etambutol Llorente | Llorente, Etambutol | Ethambutol Hydrochloride | Hydrochloride, Ethambutol | Myambutol | Miambutol | EMB-Hefa | EMB Hefa
Chemical Information
Molecular Formula C10H24N2O2
CAS Registry Number 74-55-5
SMILES CCC(CO)NCCNC(CC)CO
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Gastrointestinal pain07.01.05.005--
Generalised oedema08.01.07.004; 14.05.06.0070.001027%
Gout15.01.06.001; 14.09.01.001--Not Available
Hallucination19.10.04.003--
Headache17.14.01.001--
Hepatic failure09.01.03.0020.001027%
Hepatic function abnormal09.01.02.001--Not Available
Hepatitis09.01.07.0040.001540%Not Available
Hepatotoxicity12.03.01.008; 09.01.07.0090.001027%Not Available
Hypersensitivity10.01.03.003--
Hypoaesthesia23.03.03.081; 17.02.06.023--Not Available
Hypoglycaemia14.06.03.001; 05.06.03.0010.001027%
Hypothyroidism14.11.01.012; 05.02.03.0010.001027%
Leukopenia01.02.02.001--Not Available
Lung infiltration22.01.02.004--Not Available
Lymphadenopathy01.09.01.002--Not Available
Malaise08.01.01.0030.002054%
Myocarditis02.04.03.001--
Nausea07.01.07.0010.003081%
Nephritis20.05.02.001--Not Available
Neuritis17.09.03.001--Not Available
Neuropathy peripheral17.09.03.003--Not Available
Neutropenia01.02.03.004--Not Available
Optic neuritis10.02.01.097; 17.04.05.001; 06.04.08.0020.002054%Not Available
Paraesthesia23.03.03.094; 17.02.06.005--
Pericarditis02.06.02.001--
Pneumonia22.07.01.003; 11.01.09.003--Not Available
Pruritus23.03.12.001--
Pyrexia08.05.02.003--
Rash23.03.13.0010.001540%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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