Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ethinyl estradiol
Drug ID BADD_D00844
Description Ethinylestradiol was first synthesized in 1938 by Hans Herloff Inhoffen and Walter Hohlweg at Schering.[A191107] It was developed in an effort to create an estrogen with greater oral bioavailability.[A191107] These properties were achieved by the substitution of an ethinyl group at carbon 17 of [estradiol].[A191107] Ethinylestradiol soon replaced [mestranol] in contraceptive pills.[A191107] Ethinylestradiol was granted FDA approval on 25 June 1943.[L11884]
Indications and Usage Ethinylestradiol is combined with other drugs for use as a contraceptive, premenstrual dysphoric disorder, moderate acne, moderate to severe vasomotor symptoms of menopause, prevention of postmenopausal osteoporosis.[L11944,L11965,L11947,L11950,L11845,L9806,L11953,L10304,L11956,L11959,L11962]
Marketing Status approved
ATC Code Not Available
DrugBank ID DB00977
KEGG ID D00554
MeSH ID D004997
PubChem ID 5991
TTD Drug ID D06NXY
NDC Product Code 63190-0620; 44132-010; 65089-0044; 12860-0463; 22552-0034; 44132-002; 60870-0463
UNII 423D2T571U
Synonyms Ethinyl Estradiol | Estradiol, Ethinyl | Ethynyl Estradiol | Estradiol, Ethynyl | Ethinyloestradiol | 19-Norpregna-1,3,5(10)-trien-20-yne-3,17-diol, (17alpha)- | Ethinyl Estradiol Hemihydrate | Hemihydrate, Ethinyl Estradiol | Ethinyl Estradiol, (8 alpha)-Isomer | Ethinyl Estradiol, (8 alpha,17 alpha)-Isomer | Ethinyl Estradiol, (8 alpha,9 beta,13 alpha,14 beta)-Isomer | Progynon C | Microfollin | Microfollin Forte | Ethinyl-Oestradiol Effik | Ethinyl Oestradiol Effik | Ethinylestradiol Jenapharm | Jenapharm, Ethinylestradiol | Lynoral | Estinyl | Ethinyl Estradiol, (9 beta,17 alpha)-Isomer
Chemical Information
Molecular Formula C20H24O2
CAS Registry Number 57-63-6
SMILES CC12CCC3C(C1CCC2(C#C)O)CCC4=C3C=CC(=C4)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Abortion18.01.01.001--Not Available
Abortion spontaneous18.01.04.001--Not Available
Acne23.02.01.001--Not Available
Alopecia23.02.02.001--
Amenorrhoea21.01.02.001; 05.05.01.002--
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Angioedema22.04.02.008; 23.04.01.001; 10.01.05.009--Not Available
Anxiety19.06.02.002--
Apathy19.04.04.002--Not Available
Application site erythema08.02.01.001; 23.03.06.005; 12.07.01.001--Not Available
Application site pain12.07.01.004; 08.02.01.004--Not Available
Application site rash23.03.13.008; 12.07.01.016; 08.02.01.016--Not Available
Application site reaction08.02.01.006; 12.07.01.006--Not Available
Benign hepatic neoplasm16.06.01.001; 09.04.01.001--Not Available
Breast discharge21.05.05.001--Not Available
Breast enlargement21.05.04.001--Not Available
Breast pain21.05.05.003--
Breast tenderness21.05.05.004--Not Available
Budd-Chiari syndrome24.01.03.001; 09.01.06.001--
Carbohydrate tolerance decreased13.02.02.003--Not Available
Cataract06.06.01.001--
Cerebral haemorrhage24.07.04.001; 17.08.01.003--Not Available
Cerebral thrombosis24.01.04.003; 17.08.01.006--Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Cervical discharge21.06.01.001--Not Available
Cervix carcinoma16.12.01.001; 21.06.02.001--Not Available
Chest pain22.12.02.003; 08.01.08.002; 02.02.02.011--Not Available
Chloasma18.08.02.002; 23.05.01.001--Not Available
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ADReCS-Target
Drug Name ADR Term Target
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