Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Etonogestrel
Drug ID BADD_D00852
Description Etonogestrel molecule is a 3-ketodesogestrel or 19-nortestosterone which is a synthetic biologically active metabolite of progestin desogestrel.[A37184] The first product including etonogestrel was developed by the Merck subsidiary Organon and FDA approved in 2001.[L5692]
Indications and Usage Etonogestrel is administered in subdermal implants as long-acting reversible contraception. It is known to be effective in postpartum insertion including breastfeeding women.[A175990] Etonogestrel is part of the long-acting contraceptive implants that prevent pregnancy. The implant's effect can remain for 5 years.[L5698]
Marketing Status approved; investigational
ATC Code G03AC08
DrugBank ID DB00294
KEGG ID D04104
MeSH ID C044815
PubChem ID 6917715
TTD Drug ID D02KIU
NDC Product Code 64918-1500; 78206-145; 71161-147; 63190-0260; 45541-1192; 60870-0475; 63190-0480; 64918-1906; 65089-0053
UNII 304GTH6RNH
Synonyms etonogestrel | 13-ethyl-17-hydroxy-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-3-one | 3-oxodesogestrel | 3-ketodesogestrel | 3-oxo desogestrel | 18,19-dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-11-methylene-, (17-alpha)- | 3-keto-desogestrel | ORG-3236 | Implanon | nexplanon
Chemical Information
Molecular Formula C22H28O2
CAS Registry Number 54048-10-1
SMILES CCC12CC(=C)C3C(C1CCC2(C#C)O)CCC4=CC(=O)CCC34
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Axillary mass15.03.02.0140.000799%Not Available
Weight loss poor14.03.02.0270.002797%Not Available
Neck mass15.03.02.0070.000799%Not Available
Subclavian vein thrombosis24.01.02.0130.000235%Not Available
Uterine cervical pain21.06.01.0140.001199%Not Available
Ovarian mass21.11.02.0170.000517%Not Available
Haemorrhagic cyst24.07.01.069; 16.02.02.013; 08.03.05.0080.000235%Not Available
Polymenorrhagia21.01.03.0040.000517%Not Available
Weight bearing difficulty15.03.05.0340.000517%Not Available
Psychological trauma19.01.02.0170.000635%Not Available
Invasive ductal breast carcinoma21.05.01.021; 16.10.01.0130.000705%Not Available
Skin texture abnormal23.03.03.0680.000517%Not Available
Abnormal uterine bleeding21.01.01.0130.012060%Not Available
Administration site granuloma23.03.15.009; 12.07.04.020; 08.02.04.0200.000517%Not Available
Administration site injury12.07.04.023; 08.02.04.0230.000799%Not Available
Administration site scab23.03.03.072; 12.07.04.031; 08.02.04.0310.000917%Not Available
Anembryonic gestation18.01.03.0070.000470%Not Available
Application site bruise08.02.01.048; 24.07.06.026; 23.03.11.026; 12.07.01.0480.000799%Not Available
Application site mass12.07.01.053; 08.02.01.0530.000799%Not Available
Application site wound12.07.01.056; 08.02.01.0560.000517%Not Available
Complication of device removal08.07.01.0130.549449%Not Available
Device allergy10.01.03.054; 08.07.01.0140.000635%Not Available
Device embolisation24.01.01.039; 12.02.01.038; 08.07.05.0090.009638%Not Available
Device intolerance08.07.01.0150.001434%Not Available
Discharge08.01.03.0860.000517%Not Available
Drug physiologic incompatibility08.06.03.0090.000799%Not Available
Ectopic pregnancy with contraceptive device18.02.02.020; 08.07.04.0020.002821%Not Available
Electric shock sensation17.02.07.024; 08.06.02.0230.000752%Not Available
Encapsulation reaction08.03.05.0100.002468%Not Available
Excessive skin23.03.03.0780.000635%Not Available
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