Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Etonogestrel
Drug ID BADD_D00852
Description Etonogestrel molecule is a 3-ketodesogestrel or 19-nortestosterone which is a synthetic biologically active metabolite of progestin desogestrel.[A37184] The first product including etonogestrel was developed by the Merck subsidiary Organon and FDA approved in 2001.[L5692]
Indications and Usage Etonogestrel is administered in subdermal implants as long-acting reversible contraception. It is known to be effective in postpartum insertion including breastfeeding women.[A175990] Etonogestrel is part of the long-acting contraceptive implants that prevent pregnancy. The implant's effect can remain for 5 years.[L5698]
Marketing Status approved; investigational
ATC Code G03AC08
DrugBank ID DB00294
KEGG ID D04104
MeSH ID C044815
PubChem ID 6917715
TTD Drug ID D02KIU
NDC Product Code 64918-1500; 78206-145; 71161-147; 63190-0260; 45541-1192; 60870-0475; 63190-0480; 64918-1906; 65089-0053
UNII 304GTH6RNH
Synonyms etonogestrel | 13-ethyl-17-hydroxy-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-3-one | 3-oxodesogestrel | 3-ketodesogestrel | 3-oxo desogestrel | 18,19-dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-11-methylene-, (17-alpha)- | 3-keto-desogestrel | ORG-3236 | Implanon | nexplanon
Chemical Information
Molecular Formula C22H28O2
CAS Registry Number 54048-10-1
SMILES CCC12CC(=C)C3C(C1CCC2(C#C)O)CCC4=CC(=O)CCC34
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Foreign body reaction23.03.15.012; 08.01.05.0160.001669%Not Available
Haemoperitoneum12.01.17.007; 07.07.02.007; 24.07.02.0650.000353%Not Available
Heavy menstrual bleeding21.01.03.0050.416559%Not Available
Implant site bruising24.07.06.029; 23.03.11.032; 12.07.02.032; 08.02.02.0320.076777%Not Available
Implant site cyst16.02.02.014; 12.07.02.034; 08.02.02.0340.001387%Not Available
Implant site dehiscence12.07.02.035; 08.02.02.0350.000517%Not Available
Implant site dermatitis23.03.04.045; 12.07.02.036; 08.02.02.0360.000517%Not Available
Implant site discharge12.07.02.037; 08.02.02.0370.016056%Not Available
Implant site discolouration23.03.03.082; 08.02.02.038; 12.07.02.0380.013329%Not Available
Implant site erosion23.07.03.025; 12.07.02.039; 08.02.02.0390.002797%Not Available
Implant site erythema23.03.06.024; 12.07.02.040; 08.02.02.0400.103105%Not Available
Implant site exfoliation12.07.02.041; 08.02.02.041; 23.03.07.0100.000917%Not Available
Implant site extravasation12.07.02.042; 08.02.02.0420.003667%Not Available
Implant site fibrosis12.07.02.043; 08.02.02.0430.054585%Not Available
Implant site haematoma24.07.01.097; 12.07.02.044; 08.02.02.0440.004937%Not Available
Implant site haemorrhage24.07.01.098; 12.07.02.045; 08.02.02.0450.024589%Not Available
Implant site hypersensitivity12.07.02.046; 10.01.03.057; 08.02.02.0460.004866%Not Available
Implant site hypertrophy12.07.02.047; 08.02.02.0470.001199%Not Available
Implant site hypoaesthesia17.02.06.046; 12.07.02.048; 08.02.02.0480.025953%Not Available
Implant site induration12.07.02.049; 08.02.02.0490.007217%Not Available
Implant site inflammation12.07.02.050; 08.02.02.0500.013446%Not Available
Implant site injury12.07.02.051; 08.02.02.0510.005501%Not Available
Implant site irritation12.07.02.052; 08.02.02.0520.039164%Not Available
Implant site mass12.07.02.053; 08.02.02.0530.017208%Not Available
Implant site necrosis12.07.02.054; 08.02.02.0540.000987%Not Available
Implant site nerve injury12.07.02.055; 08.02.02.0550.002022%Not Available
Implant site nodule23.07.04.041; 12.07.02.056; 08.02.02.0560.001834%Not Available
Implant site oedema12.07.02.057; 08.02.02.0570.004702%Not Available
Implant site papules08.02.02.058; 23.03.03.083; 12.07.02.0580.001951%Not Available
Implant site paraesthesia17.02.06.047; 12.07.02.059; 08.02.02.0590.018571%Not Available
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