Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Etonogestrel
Drug ID BADD_D00852
Description Etonogestrel molecule is a 3-ketodesogestrel or 19-nortestosterone which is a synthetic biologically active metabolite of progestin desogestrel.[A37184] The first product including etonogestrel was developed by the Merck subsidiary Organon and FDA approved in 2001.[L5692]
Indications and Usage Etonogestrel is administered in subdermal implants as long-acting reversible contraception. It is known to be effective in postpartum insertion including breastfeeding women.[A175990] Etonogestrel is part of the long-acting contraceptive implants that prevent pregnancy. The implant's effect can remain for 5 years.[L5698]
Marketing Status approved; investigational
ATC Code G03AC08
DrugBank ID DB00294
KEGG ID D04104
MeSH ID C044815
PubChem ID 6917715
TTD Drug ID D02KIU
NDC Product Code 64918-1500; 78206-145; 71161-147; 63190-0260; 45541-1192; 60870-0475; 63190-0480; 64918-1906; 65089-0053
UNII 304GTH6RNH
Synonyms etonogestrel | 13-ethyl-17-hydroxy-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-3-one | 3-oxodesogestrel | 3-ketodesogestrel | 3-oxo desogestrel | 18,19-dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-11-methylene-, (17-alpha)- | 3-keto-desogestrel | ORG-3236 | Implanon | nexplanon
Chemical Information
Molecular Formula C22H28O2
CAS Registry Number 54048-10-1
SMILES CCC12CC(=C)C3C(C1CCC2(C#C)O)CCC4=CC(=O)CCC34
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Fibroadenoma of breast21.05.01.005; 16.14.01.001--Not Available
Fibrosis08.03.01.0010.003103%Not Available
Flatulence07.01.04.002--
Fluid retention20.01.02.003; 14.05.06.002--Not Available
Galactorrhoea21.05.02.002; 05.03.04.0020.004067%Not Available
Gastritis07.08.02.001--
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal pain07.01.05.005--
Generalised oedema08.01.07.004; 14.05.06.007--
Gestational diabetes18.02.04.001; 14.06.01.008; 05.06.01.0080.000987%Not Available
Haematoma24.07.01.001--
Haemoglobin13.01.05.018--Not Available
Haemorrhagic disorder24.07.01.021; 01.01.03.0040.001199%Not Available
Hair growth abnormal23.02.06.0060.001316%Not Available
Headache17.14.01.0010.188792%
Hepatic neoplasm16.07.03.001; 09.04.03.001--Not Available
Hepatocellular injury09.01.07.008--Not Available
Hereditary angioedema23.04.01.015; 10.01.05.012; 03.20.03.002--Not Available
Hidradenitis23.02.03.0130.000917%Not Available
Hodgkin's disease16.31.01.001; 01.16.01.0010.000235%Not Available
Hyperphagia19.09.01.005; 14.03.01.007; 07.01.06.0180.001199%Not Available
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hypertrichosis23.02.04.002--
Hypoaesthesia23.03.03.081; 17.02.06.0230.095865%Not Available
Hypomenorrhoea21.01.02.002; 05.05.01.0060.026846%Not Available
Immune system disorder10.02.01.001--Not Available
Impaired healing08.03.02.0010.016620%Not Available
Implant site reaction12.07.02.009; 08.02.02.0090.022144%Not Available
Increased appetite14.03.01.003; 08.01.09.0270.004349%Not Available
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