Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Etonogestrel
Drug ID BADD_D00852
Description Etonogestrel molecule is a 3-ketodesogestrel or 19-nortestosterone which is a synthetic biologically active metabolite of progestin desogestrel.[A37184] The first product including etonogestrel was developed by the Merck subsidiary Organon and FDA approved in 2001.[L5692]
Indications and Usage Etonogestrel is administered in subdermal implants as long-acting reversible contraception. It is known to be effective in postpartum insertion including breastfeeding women.[A175990] Etonogestrel is part of the long-acting contraceptive implants that prevent pregnancy. The implant's effect can remain for 5 years.[L5698]
Marketing Status approved; investigational
ATC Code G03AC08
DrugBank ID DB00294
KEGG ID D04104
MeSH ID C044815
PubChem ID 6917715
TTD Drug ID D02KIU
NDC Product Code 64918-1500; 78206-145; 71161-147; 63190-0260; 45541-1192; 60870-0475; 63190-0480; 64918-1906; 65089-0053
UNII 304GTH6RNH
Synonyms etonogestrel | 13-ethyl-17-hydroxy-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-3-one | 3-oxodesogestrel | 3-ketodesogestrel | 3-oxo desogestrel | 18,19-dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-11-methylene-, (17-alpha)- | 3-keto-desogestrel | ORG-3236 | Implanon | nexplanon
Chemical Information
Molecular Formula C22H28O2
CAS Registry Number 54048-10-1
SMILES CCC12CC(=C)C3C(C1CCC2(C#C)O)CCC4=CC(=O)CCC34
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Vaginal infection21.14.02.002; 11.01.10.002--
Vaginal odour21.08.02.0080.002398%Not Available
Varicose vein24.10.04.001--Not Available
Vasodilatation24.03.02.003; 23.06.05.0060.001199%Not Available
Vein discolouration24.03.02.0040.000799%Not Available
Visual impairment06.02.10.013--Not Available
Vomiting07.01.07.003--
Vulvovaginal discomfort21.08.02.0050.001199%Not Available
Vulvovaginal dryness21.08.02.0030.004349%
Weight decreased13.15.01.005--
Weight increased13.15.01.006--
Mobility decreased08.01.03.030; 15.03.05.023; 17.02.05.0180.007381%Not Available
Axillary pain08.01.08.0150.003268%Not Available
Scar pain23.03.03.0600.000635%Not Available
Weight fluctuation14.03.02.0020.004631%Not Available
Food aversion19.09.03.002; 14.03.02.0290.000517%Not Available
Contusion15.03.05.007; 24.07.06.001; 23.03.11.002; 12.01.06.001--
Skin induration23.03.03.0200.000235%
Application site discharge23.03.03.049; 12.07.01.039; 08.02.01.0390.000917%Not Available
Foetor hepaticus07.01.06.026; 09.01.05.006--Not Available
Musculoskeletal discomfort15.03.04.0010.003150%Not Available
Skin swelling23.03.03.0390.000517%Not Available
Secretion discharge08.01.03.0190.001599%Not Available
Limb deformity15.10.03.0040.000917%Not Available
Medical device discomfort08.07.01.0100.014175%Not Available
Nodule08.03.05.0020.002116%Not Available
Affect lability19.04.01.001--Not Available
Haemorrhage24.07.01.0020.074238%Not Available
Food craving19.09.01.010; 14.03.01.0090.001599%Not Available
Vulvovaginal pruritus23.03.12.009; 21.08.02.0040.002351%Not Available
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