Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Etonogestrel
Drug ID BADD_D00852
Description Etonogestrel molecule is a 3-ketodesogestrel or 19-nortestosterone which is a synthetic biologically active metabolite of progestin desogestrel.[A37184] The first product including etonogestrel was developed by the Merck subsidiary Organon and FDA approved in 2001.[L5692]
Indications and Usage Etonogestrel is administered in subdermal implants as long-acting reversible contraception. It is known to be effective in postpartum insertion including breastfeeding women.[A175990] Etonogestrel is part of the long-acting contraceptive implants that prevent pregnancy. The implant's effect can remain for 5 years.[L5698]
Marketing Status approved; investigational
ATC Code G03AC08
DrugBank ID DB00294
KEGG ID D04104
MeSH ID C044815
PubChem ID 6917715
TTD Drug ID D02KIU
NDC Product Code 64918-1500; 78206-145; 71161-147; 63190-0260; 45541-1192; 60870-0475; 63190-0480; 64918-1906; 65089-0053
UNII 304GTH6RNH
Synonyms etonogestrel | 13-ethyl-17-hydroxy-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-3-one | 3-oxodesogestrel | 3-ketodesogestrel | 3-oxo desogestrel | 18,19-dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-11-methylene-, (17-alpha)- | 3-keto-desogestrel | ORG-3236 | Implanon | nexplanon
Chemical Information
Molecular Formula C22H28O2
CAS Registry Number 54048-10-1
SMILES CCC12CC(=C)C3C(C1CCC2(C#C)O)CCC4=CC(=O)CCC34
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Genital discharge21.10.01.006--Not Available
Anxiety disorder19.06.01.0020.000235%Not Available
Adnexa uteri pain21.07.04.0060.003432%Not Available
Disturbance in sexual arousal19.08.04.003--Not Available
Angiopathy24.03.02.007--Not Available
Adhesion08.01.03.0480.000917%Not Available
Induration08.01.03.0200.000517%Not Available
Hot flush24.03.01.005; 08.01.03.027; 21.02.02.001--
Neurological symptom17.02.05.0100.001316%Not Available
General symptom08.01.03.0210.001199%Not Available
Adverse event08.06.01.0100.179623%Not Available
Benign neoplasm16.02.02.0070.000799%Not Available
Breast disorder21.05.04.004--Not Available
Connective tissue disorder10.04.04.026; 15.06.01.006--Not Available
Infestation23.11.01.002; 11.09.01.001--Not Available
Libido disorder21.03.02.006; 19.08.03.0040.000799%Not Available
Limb discomfort15.03.04.0140.045793%Not Available
Lactation disorder18.06.02.003; 21.05.02.0040.001199%
Malnutrition14.03.02.004--Not Available
Mental disorder19.07.01.002--Not Available
Soft tissue disorder15.03.02.0120.000799%
Spinal disorder15.02.04.0230.004514%Not Available
Venous thrombosis limb24.01.02.0090.000235%Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Feeling of body temperature change08.01.09.0120.000799%Not Available
Complication of delivery18.07.04.0030.000470%Not Available
Genital pain21.10.01.0080.000799%Not Available
Poor quality sleep17.15.04.002; 19.02.05.0050.003832%Not Available
Application site discomfort12.07.01.034; 08.02.01.0340.011096%Not Available
Excessive granulation tissue23.07.04.012; 08.03.02.0030.001034%Not Available
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