Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Exemestane
Drug ID BADD_D00861
Description Exemestane is an oral steroidal aromatase inhibitor used in the adjuvant treatment of hormonally-responsive (also called hormone-receptor-positive, estrogen-responsive) breast cancer in postmenopausal women. It irreversibly binds to the active site of the enzyme resulting in permanent inhibition.
Indications and Usage For the treatment of advanced breast cancer in postmenopausal women whose disease has progressed following tamoxifen therapy.
Marketing Status approved; investigational
ATC Code L02BG06
DrugBank ID DB00990
KEGG ID D00963
MeSH ID C056516
PubChem ID 60198
TTD Drug ID D0D2VS
NDC Product Code 62157-091; 65129-1217; 44278-025; 71921-190; 51552-1619; 65427-030; 68724-1003; 51991-005; 63629-2056; 68382-383; 49386-026; 73377-132; 46439-8746; 59762-2858; 70771-1374; 65162-240; 0054-0080; 69097-316; 59057-007; 64918-0622; 64181-0005; 59651-516; 52128-134; 64918-0621; 53104-7666; 59057-008; 0832-0595; 65089-0046; 0009-7663
UNII NY22HMQ4BX
Synonyms exemestane | examestane | 6-methyleneandrosta-1,4-diene-3,17-dione | FCE 24304 | FCE-24304 | Aromasil | Aromasin | Aromasine
Chemical Information
Molecular Formula C20H24O2
CAS Registry Number 107868-30-4
SMILES CC12CCC3C(C1CCC2=O)CC(=C)C4=CC(=O)C=CC34C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Swelling face08.01.03.100; 23.04.01.018; 10.01.05.0180.004078%Not Available
Tachycardia02.03.02.007--Not Available
Tenderness08.01.08.0050.001046%Not Available
Tendonitis15.07.01.003; 12.01.07.007--Not Available
Therapeutic response unexpected08.06.01.0010.004078%Not Available
Thinking abnormal19.10.03.001; 17.02.05.0230.003555%Not Available
Thrombocytopenia01.08.01.002--Not Available
Thrombosis24.01.01.0060.005751%Not Available
Tinnitus17.04.07.004; 04.04.01.0020.005856%
Transient ischaemic attack24.04.06.005; 17.08.04.0010.001568%
Trigger finger15.07.01.0050.002300%Not Available
Upper respiratory tract infection22.07.03.011; 11.01.13.009--
Urinary tract infection20.08.02.001; 11.01.14.004--
Urticaria23.04.02.001; 10.01.06.001--
Uterine haemorrhage21.07.01.005; 24.07.03.004--
Uterine polyp21.07.02.001; 16.04.02.002--Not Available
Vaginal haemorrhage24.07.03.005; 21.08.01.0010.004705%
Varicose vein24.10.04.0010.001046%Not Available
Viral infection11.05.04.001--Not Available
Visual impairment06.02.10.0130.006379%Not Available
Vomiting07.01.07.003--
Vulvovaginal dryness21.08.02.003--
Weight increased13.15.01.006--
Musculoskeletal disorder15.03.05.0250.004078%Not Available
Acute generalised exanthematous pustulosis11.07.01.018; 10.01.01.034; 23.03.10.002; 12.03.01.005--Not Available
Hypoacusis04.02.01.0060.008156%
Peripheral swelling08.01.03.053; 02.05.04.0150.012966%Not Available
Osteopenia15.02.03.003; 14.04.04.0040.005647%Not Available
Left ventricular hypertrophy02.04.02.0140.001046%Not Available
Balance disorder08.01.03.081; 17.02.02.0070.004601%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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