Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Exemestane
Drug ID BADD_D00861
Description Exemestane is an oral steroidal aromatase inhibitor used in the adjuvant treatment of hormonally-responsive (also called hormone-receptor-positive, estrogen-responsive) breast cancer in postmenopausal women. It irreversibly binds to the active site of the enzyme resulting in permanent inhibition.
Indications and Usage For the treatment of advanced breast cancer in postmenopausal women whose disease has progressed following tamoxifen therapy.
Marketing Status approved; investigational
ATC Code L02BG06
DrugBank ID DB00990
KEGG ID D00963
MeSH ID C056516
PubChem ID 60198
TTD Drug ID D0D2VS
NDC Product Code 62157-091; 65129-1217; 44278-025; 71921-190; 51552-1619; 65427-030; 68724-1003; 51991-005; 63629-2056; 68382-383; 49386-026; 73377-132; 46439-8746; 59762-2858; 70771-1374; 65162-240; 0054-0080; 69097-316; 59057-007; 64918-0622; 64181-0005; 59651-516; 52128-134; 64918-0621; 53104-7666; 59057-008; 0832-0595; 65089-0046; 0009-7663
UNII NY22HMQ4BX
Synonyms exemestane | examestane | 6-methyleneandrosta-1,4-diene-3,17-dione | FCE 24304 | FCE-24304 | Aromasil | Aromasin | Aromasine
Chemical Information
Molecular Formula C20H24O2
CAS Registry Number 107868-30-4
SMILES CC12CCC3C(C1CCC2=O)CC(=C)C4=CC(=O)C=CC34C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Urogenital haemorrhage20.08.01.006; 24.07.01.044; 21.10.05.0080.001046%Not Available
Musculoskeletal chest pain15.03.04.012; 22.09.01.0010.002300%
Deep vein thrombosis24.01.02.003--Not Available
Acute coronary syndrome24.04.04.011; 02.02.02.015--Not Available
Musculoskeletal stiffness15.03.05.0270.005333%Not Available
Musculoskeletal discomfort15.03.04.0010.002823%Not Available
Haemorrhage24.07.01.002--Not Available
Postmenopausal haemorrhage24.07.03.002; 21.02.01.0020.001046%Not Available
Pulmonary mass22.02.07.0040.001046%Not Available
Breast cancer female21.05.01.011; 16.10.01.0040.007947%Not Available
Cognitive disorder19.21.02.001; 17.03.03.0030.004601%
Toxic skin eruption12.03.01.073; 23.03.05.003; 10.01.01.0080.001046%Not Available
Hot flush08.01.03.027; 24.03.01.005; 21.02.02.0010.032834%
Brain neoplasm17.20.01.003; 16.30.01.003--Not Available
Cardiac disorder02.11.01.003--Not Available
Embolism24.01.01.009--
Ischaemic stroke17.08.01.018; 24.04.06.0100.003137%Not Available
Mental disorder19.07.01.002--Not Available
Neoplasm progression16.16.02.0050.120147%Not Available
Abnormal behaviour19.01.01.0010.002300%Not Available
Decreased appetite14.03.01.005; 08.01.09.0280.010038%
Polyp16.02.02.005; 08.01.06.010--Not Available
Disease progression08.01.03.0380.085326%
Disease recurrence08.01.03.0500.003346%Not Available
Drug intolerance08.06.01.0130.021854%Not Available
Neoplasm recurrence16.16.02.0040.009411%Not Available
Hepatobiliary disease09.01.08.003--Not Available
Arterial occlusive disease24.04.02.021--Not Available
Uterine mass21.07.01.0120.001046%Not Available
Osteonecrosis of jaw15.02.04.010; 24.04.05.0050.006797%
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ADReCS-Target
Drug Name ADR Term Target
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