Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Exemestane
Drug ID BADD_D00861
Description Exemestane is an oral steroidal aromatase inhibitor used in the adjuvant treatment of hormonally-responsive (also called hormone-receptor-positive, estrogen-responsive) breast cancer in postmenopausal women. It irreversibly binds to the active site of the enzyme resulting in permanent inhibition.
Indications and Usage For the treatment of advanced breast cancer in postmenopausal women whose disease has progressed following tamoxifen therapy.
Marketing Status approved; investigational
ATC Code L02BG06
DrugBank ID DB00990
KEGG ID D00963
MeSH ID C056516
PubChem ID 60198
TTD Drug ID D0D2VS
NDC Product Code 62157-091; 65129-1217; 44278-025; 71921-190; 51552-1619; 65427-030; 68724-1003; 51991-005; 63629-2056; 68382-383; 49386-026; 73377-132; 46439-8746; 59762-2858; 70771-1374; 65162-240; 0054-0080; 69097-316; 59057-007; 64918-0622; 64181-0005; 59651-516; 52128-134; 64918-0621; 53104-7666; 59057-008; 0832-0595; 65089-0046; 0009-7663
UNII NY22HMQ4BX
Synonyms exemestane | examestane | 6-methyleneandrosta-1,4-diene-3,17-dione | FCE 24304 | FCE-24304 | Aromasil | Aromasin | Aromasine
Chemical Information
Molecular Formula C20H24O2
CAS Registry Number 107868-30-4
SMILES CC12CCC3C(C1CCC2=O)CC(=C)C4=CC(=O)C=CC34C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.0030.010979%
Acute hepatic failure09.01.03.0010.001568%Not Available
Alopecia23.02.02.0010.019868%
Amnesia19.20.01.001; 17.03.02.001--
Angina pectoris24.04.04.002; 02.02.02.002--
Anxiety19.06.02.002--
Arrhythmia02.03.02.0010.001046%Not Available
Arthralgia15.01.02.0010.070164%
Arthritis15.01.01.0010.004078%
Arthropathy15.01.01.0030.002091%Not Available
Ascites09.01.05.003; 07.07.01.001; 02.05.04.0020.001568%
Asthenia08.01.01.001--Not Available
Back pain15.03.04.0050.012757%
Body temperature increased13.15.01.001--Not Available
Bone disorder15.02.04.0040.006692%Not Available
Bone pain15.02.01.0010.015790%
Breast cancer21.05.01.003; 16.10.01.0010.042036%Not Available
Breast pain21.05.05.0030.002300%
Breast swelling21.05.05.0080.002300%Not Available
Bronchitis22.07.01.001; 11.01.09.001--
Cardiac failure02.05.01.0010.002091%
Cardiomyopathy02.04.01.0010.001046%Not Available
Cardiovascular disorder02.11.01.010; 24.03.02.009--Not Available
Carpal tunnel syndrome17.09.02.0010.002091%Not Available
Cataract06.06.01.0010.001568%
Cerebral atrophy17.11.01.0010.001046%Not Available
Cerebral infarction24.04.06.002; 17.08.01.0040.001568%Not Available
Cerebral ischaemia24.04.06.003; 17.08.01.0050.001046%
Cerebrovascular accident24.03.05.001; 17.08.01.0070.007529%
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ADReCS-Target
Drug Name ADR Term Target
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