Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Extendin-4
Drug ID BADD_D00863
Description Exenatide is a glucagon-like peptide-1 (GLP-1) analog[Label]. It functions to activate the GLP-1 receptor and increases insulin secretion, decrease glucagon secretion, and slow gastric emptying to improve glycemic control[Label]. Exenatide was given FDA approval on April 28, 2005[L6106].
Indications and Usage Exenatide is indicated for improving glycemic control in adults with type 2 diabetes mellitus along with diet and exercise[Label].
Marketing Status approved; investigational
ATC Code A10BJ01
DrugBank ID DB01276
KEGG ID D04121
MeSH ID D000077270
PubChem ID 16157882
TTD Drug ID D00YVF
NDC Product Code 52416-125; 0310-6540; 41524-0003; 69766-078; 68067-0397; 0310-6512; 0310-6524; 52416-105; 0406-7310; 59149-004
UNII 9P1872D4OL
Synonyms Exenatide | Bydureon | ITCA 650 | AC 2993 LAR | Exendin-4 | Ex4 Peptide | Peptide, Ex4 | Exendin 4 | Byetta | AC 2993
Chemical Information
Molecular Formula C184H282N50O60S
CAS Registry Number 141758-74-9
SMILES CCC(C)C(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CC(C)C)C(=O)NC(CCCCN )C(=O)NC(CC(=O)N)C(=O)NCC(=O)NCC(=O)N3CCCC3C(=O)NC(CO)C(=O)NC(CO)C(=O)NCC(=O)NC( C)C(=O)N4CCCC4C(=O)N5CCCC5C(=O)N6CCCC6C(=O)NC(CO)C(=O)N)NC(=O)C(CC7=CC=CC=C7)NC( =O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(C(C)C)NC(=O)C(C)NC(=O)C(CCC(=O)O)NC(=O)C( CCC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CCSC)NC(=O)C(CCC(=O)N)NC(=O)C(CCCCN)NC(=O)C(CO )NC(=O)C(CC(C)C)NC(=O)C(CC(=O)O)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C(CC8=CC=CC=C8)NC (=O)C(C(C)O)NC(=O)CNC(=O)C(CCC(=O)O)NC(=O)CNC(=O)C(CC9=CN=CN9)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Musculoskeletal pain15.03.04.007--
Nasopharyngitis22.07.03.002; 11.01.13.002--Not Available
Nausea07.01.07.001--
Nervous system disorder17.02.10.001--Not Available
Nervousness19.06.02.003--Not Available
Pain in extremity15.03.04.010--
Pancreatitis acute07.18.01.002--Not Available
Pancreatitis necrotising07.18.01.004--Not Available
Pruritus23.03.12.001--
Rash papular23.03.13.017--Not Available
Renal failure20.01.03.005--Not Available
Seizure17.12.03.001--
Sinusitis11.01.13.005; 22.07.03.007--
Skin disorder23.03.03.007--Not Available
Somnolence19.02.05.003; 17.02.04.006--
Tachycardia02.03.02.007--Not Available
Toothache07.09.06.001--
Upper respiratory tract infection22.07.03.011; 11.01.13.009--
Urethral disorder20.07.01.002--Not Available
Urinary tract disorder20.08.01.001--Not Available
Urinary tract infection20.08.02.001; 11.01.14.004--
Urticaria10.01.06.001; 23.04.02.001--
Vomiting07.01.07.003--
Weight decreased13.15.01.005--
Viral diarrhoea11.05.04.012; 07.19.02.008--Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Nodule08.03.05.002--Not Available
Neuroglycopenia05.06.03.009; 17.02.05.046; 14.06.03.009--Not Available
Haemorrhage24.07.01.002--Not Available
Injection site nodule12.07.03.034; 08.02.03.034; 23.07.04.009--Not Available
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