Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Felodipine
Drug ID BADD_D00872
Description Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte contraction and vasoconstriction. Felodipine is the most potent CCB in use and is unique in that it exhibits fluorescent activity. In addition to binding to L-type calcium channels, felodipine binds to a number of calcium-binding proteins, exhibits competitive antagonism of the mineralcorticoid receptor, inhibits the activity of calmodulin-dependent cyclic nucleotide phosphodiesterase, and blocks calcium influx through voltage-gated T-type calcium channels. Felodipine is used to treat mild to moderate essential hypertension.
Indications and Usage For the treatment of mild to moderate essential hypertension.
Marketing Status approved; investigational
ATC Code C08CA02
DrugBank ID DB01023
KEGG ID D00319
MeSH ID D015736
PubChem ID 3333
TTD Drug ID D0WN0U
NDC Product Code 13668-134; 53489-368; 53489-369; 53489-370; 63629-2018; 53104-7519; 63629-2017; 69367-266; 0603-3581; 0603-3582; 65862-399; 66406-0276; 63629-2196; 63629-9301; 0603-3583; 57237-110; 61442-432; 63629-2016; 65862-673; 65862-675; 69367-265; 71205-922; 72162-1159; 62135-646; 69367-264; 14799-2007; 66406-0277; 13668-133; 51407-087; 51407-089; 57237-109; 61442-433; 62135-647; 13668-132; 50090-5870; 57237-108; 63629-2191; 63629-2194; 68462-233; 68462-234; 53296-0041; 23155-049; 51407-088; 61442-431; 62135-648; 63629-2195; 65862-674; 68462-235; 71335-1486; 71335-2175; 72162-1158; 72162-1160; 66406-0275; 63629-2193; 71205-920; 23155-048; 63629-2192; 71205-921; 71335-1318; 65035-105; 23155-050
UNII OL961R6O2C
Synonyms Felodipine | Felo Biochemie | Felo-Puren | Felo Puren | Felobeta | Felocor | Felodipin 1A Pharma | Felodipin AbZ | Felodipin AL | Felodipin AZU | Felodipin Dura | Felodipin Heumann | Heumann, Felodipin | Felodipin Stada | Felodipin Von Ct | Von Ct, Felodipin | Felodipin-Ratiopharm | Felodipin Ratiopharm | Felodur | Felogamma | Fensel | H 154-82 | H 154 82 | H 15482 | Perfudal | Plendil | Flodil | Modip | Renedil | Munobal | Agon
Chemical Information
Molecular Formula C18H19Cl2NO4
CAS Registry Number 72509-76-3
SMILES CCOC(=O)C1=C(NC(=C(C1C2=C(C(=CC=C2)Cl)Cl)C(=O)OC)C)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Photosensitivity reaction23.03.09.003--
Pollakiuria20.02.02.007--
Polyuria20.02.03.002--Not Available
Pruritus23.03.12.0010.001608%
Rash23.03.13.001--Not Available
Rhinorrhoea22.12.03.021--
Salivary gland enlargement07.06.03.002--Not Available
Sexual dysfunction19.08.05.002; 21.03.02.003--Not Available
Shock24.06.02.002--Not Available
Sinusitis22.07.03.007; 11.01.13.005--
Skin irritation23.03.04.0090.000357%Not Available
Sneezing22.12.03.024--
Somnolence19.02.05.003; 17.02.04.006--
Swelling08.01.03.015--Not Available
Syncope02.11.04.015; 24.06.02.012; 17.02.04.008--
Tachycardia02.03.02.0070.000357%Not Available
Tenderness08.01.08.005--Not Available
Tension19.06.02.005--Not Available
Therapeutic response decreased08.06.01.016--Not Available
Tremor17.01.06.002--
Upper respiratory tract infection22.07.03.011; 11.01.13.009--
Urinary retention20.02.02.0110.000536%
Urticaria23.04.02.001; 10.01.06.0010.000357%
Vertigo17.02.12.002; 04.04.01.003--
Visual field defect17.17.01.001; 06.02.07.003--Not Available
Visual impairment06.02.10.013--Not Available
Vomiting07.01.07.003--
Peripheral swelling08.01.03.053; 02.05.04.015--Not Available
Chapped lips07.05.01.0040.000357%Not Available
Contusion15.03.05.007; 24.07.06.001; 23.03.11.002; 12.01.06.001--
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