Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ferrosoferric oxide
Drug ID BADD_D00886
Description Ferumoxytol is an intravenously administered iron preparation indicated in the EU and the US for the treatment of iron deficiency anemia in adult patients with chronic kidney disease (CKD) [A32478]. It is comprised of superparamagnetic iron oxide nanoparticles which are coated by a semi-synthetic carbohydrate shell in an isotonic, neutral pH solution that may be administered at relatively high dose by rapid intravenous injection [L2181].
Indications and Usage This drug is indicated for the treatment of iron deficiency anemia in adult patients who have experienced intolerance to oral iron or have experienced an unsatisfactory response to oral iron or who have chronic kidney disease (CKD) [FDA label].
Marketing Status approved; investigational
ATC Code Not Available
DrugBank ID DB06215
KEGG ID D04177; D09142
MeSH ID D052203
PubChem ID 14789
TTD Drug ID D06CTM
NDC Product Code 69766-104; 0781-3154; 59338-775; 42973-331
UNII XM0M87F357
Synonyms Ferrosoferric Oxide | Oxide, Ferrosoferric | Ferriferrous Oxide | Oxide, Ferriferrous | Magnetite | Feraheme | Ferumoxytol
Chemical Information
Molecular Formula Fe3H2O4
CAS Registry Number 1317-61-9
SMILES O[Fe]=O.O[Fe]=O.[Fe]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Swollen tongue23.04.01.014; 10.01.05.015; 07.14.02.003--Not Available
Syncope02.11.04.015; 24.06.02.012; 17.02.04.008--
Tachycardia02.03.02.007--Not Available
Throat irritation22.12.03.029; 07.05.05.037--Not Available
Throat tightness22.12.03.031; 19.01.02.005--Not Available
Urticaria23.04.02.001; 10.01.06.001--
Vision blurred17.17.01.010; 06.02.06.007--
Vomiting07.01.07.003--
Wheezing22.03.01.009--
Contusion15.03.05.007; 24.07.06.001; 23.03.11.002; 12.01.06.001--
Injection site discolouration12.07.03.038; 08.02.03.038; 23.03.03.046--Not Available
Acute coronary syndrome24.04.04.011; 02.02.02.015--Not Available
Lymphatic disorder01.09.01.003--Not Available
Musculoskeletal stiffness15.03.05.027--Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Infusion site swelling12.07.05.003; 08.02.05.002--Not Available
Haemorrhage24.07.01.002--Not Available
Vasodilation procedure25.03.01.001--Not Available
Angiopathy24.03.02.007--Not Available
Hot flush24.03.01.005; 21.02.02.001; 08.01.03.027--
Malnutrition14.03.02.004--Not Available
Mediastinal disorder22.09.03.001--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Blood disorder01.05.01.004--Not Available
Hepatobiliary disease09.01.08.003--Not Available
Chronic kidney disease20.01.03.017--
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