| Drug Name |
Fosfomycin |
| Drug ID |
BADD_D00965 |
| Description |
Fosfomycin was discovered in 1969 by scientists at the Spanish Penicillin and Antibiotics Company and is produced by _Streptomyces fradiae_.[A229338,A230348] It may also be produced synthetically and is commercially available as the disodium salt for intravenous administration and as the calcium or trometamol salt for oral administration.[A230348] In terms of chemical structure, fosfomycin is a phosphoenolpyruvate analog and contains a phosphonic group and an epoxide ring.[A230348]
Due to its ease of administration as a single 3-gram oral dose and desirable safety profile, fosfomycin has largely become a first-line therapeutic option for the treatment of uncomplicated urinary tract infections (UTIs) in females.[A230378] Despite being FDA approved only for urinary tract infections, fosfomycin actually has a broad spectrum of activity and is active against both gram-positive and gram-negative bacteria.[A230348] As such there is great interest in exploring the usefulness of fosfomycin for indications beyond the treatment of UTIs.[A230353,A230358] |
| Indications and Usage |
Fosfomycin is indicated for the treatment of uncomplicated cases of cystitis caused by susceptible strains of _Escherichia coli_ and _Enterococcus faecalis_.[L31818] Fosfomycin is not officially indicated for the treatment of pyelonephritis or perinephric abscess, although there have been reported cases of off-label usage in these situations.[L31818] |
| Marketing Status |
approved |
| ATC Code |
J01XX01; S02AA17 |
| DrugBank ID |
DB00828
|
| KEGG ID |
D04253
|
| MeSH ID |
D005578
|
| PubChem ID |
446987
|
| TTD Drug ID |
D01GYT
|
| NDC Product Code |
Not Available |
| UNII |
2N81MY12TE
|
| Synonyms |
Fosfomycin | Phosphomycin | Phosphonomycin | Monuril | Fosfomycin Trometamol Salt | Fosfomycin Tromethamine | Tromethamine, Fosfomycin |
