| Pharmaceutical Information |
| Drug Name |
Fosinopril sodium |
| Drug ID |
BADD_D00968 |
| Description |
Fosinopril is a phosphinic acid-containing ester prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly hydrolyzed to fosinoprilat, its principle active metabolite. Fosinoprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Fosinopril may be used to treat mild to moderate hypertension, as an adjunct in the treatment of congestive heart failure, and to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and microalbuminuria or overt nephropathy. |
| Indications and Usage |
For treating mild to moderate hypertension, use as an adjunct in treating congestive heart failure, and may be used to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and microalbuminuria or overt nephropathy. |
| Marketing Status |
approved |
| ATC Code |
C09AA09 |
| DrugBank ID |
DB00492
|
| KEGG ID |
D00622
|
| MeSH ID |
D017328
|
| PubChem ID |
23666105
|
| TTD Drug ID |
D0X8KY
|
| NDC Product Code |
76282-201; 76282-202; 65862-393; 65977-0004; 65862-472; 65862-471; 62135-042; 62135-043; 71335-1115; 16571-772; 71335-9703; 43547-388; 65862-473; 76282-200; 43547-387; 62135-041; 16571-770; 16571-771 |
| UNII |
NW2RTH6T2N
|
| Synonyms |
Fosinopril | Fosenopril | Fosinil | Fositens | Fosinopril Sodium | Sodium, Fosinopril | Fosinopril, (1(S*(R*)),2 alpha,4 beta)-Isomer | Fosinopril, (1(S*(R*)),2 alpha,4 alpha)-(D-Pro)-Isomer | Tenso Stop | Tensocardil | Fozitec | Hiperlex | Monopril | Fosinorm | Newace | Staril | SQ-28,555 | SQ 28,555 | SQ28,555 | SQ-28555 | SQ 28555 | SQ28555 | Dynacil | Fosinopril, (1(S*(S*)),2 alpha,4 beta)-Isomer |
|
| Chemical Information |
| Molecular Formula |
C30H45NNaO7P |
| CAS Registry Number |
88889-14-9 |
| SMILES |
CCC(=O)OC(C(C)C)OP(=O)(CCCCC1=CC=CC=C1)CC(=O)N2CC(CC2C(=O)[O-])C3CCCCC3.[Na+] |
| Chemical Structure |
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| ADRs Induced by Drug |
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