Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Gabapentin enacarbil
Drug ID BADD_D00982
Description Gabapentin enacarbil is marketed under the name Horizant. It is a prodrug of gabapentin, and indicated in adults for the treatment of Restless Legs Syndrome (RLS) and postherpetic neuralgia (PHN).
Indications and Usage For the treatment of adult Restless Legs Syndrome (RLS) and postherpetic neuralgia (PHN).
Marketing Status approved; investigational
ATC Code Not Available
DrugBank ID DB08872
KEGG ID D09539
MeSH ID C493250
PubChem ID 9883933
TTD Drug ID D05KBU
NDC Product Code 49187-0710; 70966-0011; 53451-0103; 53451-0101; 66039-945
UNII 75OCL1SPBQ
Synonyms 1-(((alpha-isobutanoyloxyethoxy)carbonyl)aminomethyl)-1-cyclohexaneacetic acid | gabapentin enacarbil | XP 12464 | XP12464 | XP-12464 | XP 10569 | XP10569 | XP-10569 | XP 11239 | XP11239 | XP-11239 | XP 13512 | XP13512 | XP-13512 | XP 11084 | XP11084 | XP-11084
Chemical Information
Molecular Formula C16H27NO6
CAS Registry Number 478296-72-9
SMILES CC(C)C(=O)OC(C)OC(=O)NCC1(CCCCC1)CC(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Cardio-respiratory arrest22.02.06.007; 02.03.04.002-Not Available
Chorea17.01.01.001-Not Available
Coma17.02.09.001-Not Available
Completed suicide08.04.01.010; 19.12.01.001-Not Available
Death08.04.01.001-
Depressed level of consciousness17.02.04.002-
Depression19.15.01.001--
Disorientation19.13.01.002; 17.02.05.015--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.11.04.006-
Drug abuse19.07.06.010-Not Available
Drug eruption23.03.05.001; 10.01.01.005; 08.01.06.015-Not Available
Drug hypersensitivity10.01.01.001-Not Available
Drug interaction08.06.03.001-Not Available
Drug withdrawal syndrome neonatal19.07.06.014; 18.04.13.001; 08.06.02.008-Not Available
Dry mouth07.06.01.002--
Dyskinesia17.01.02.006-
Dysphagia07.01.06.003-
Dystonia17.01.03.001-Not Available
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014-Not Available
Feeling drunk08.01.09.015--Not Available
Flatulence07.01.04.002--
Gait disturbance15.03.05.013; 17.02.05.016; 08.01.02.002-
Gastric cancer07.21.02.001; 16.13.03.001-Not Available
Gastrointestinal disorder07.11.01.001-Not Available
Headache17.14.01.001--
Hypersensitivity10.01.03.003-
Hypoxia22.02.02.003-
Increased appetite14.03.01.003; 08.01.09.027--Not Available
Insomnia19.02.01.002; 17.15.03.002-
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