| Drug Name |
Gadobutrol |
| Drug ID |
BADD_D00984 |
| Description |
Intravenous gadobutrol is a second-generation extracellular non-ionic macrocyclic GBCA (gadolinium-based contrast agent) used in magnetic resonance imaging (MRI) in adults and children older than 2 years of age. It may help visualize and detect vascular abnormalities in the blood brain barrier (BBB) and central nervous system (CNS).
In patients with impaired renal function, gadolinium based contrast agents increase the risk of nephrogenic systemic fibrosis (NSF). A physician should be contacted if symptoms of NSF are encountered, such as dark or red patches on the skin; stiffness in joints; trouble moving, bending or straightening arms, hands, legs or feet; burning, itching, swelling, scaling, hardening and tightening of skin; pain in hip bones or ribs; or muscle weakness.
Common adverse reactions that may be experienced include headache, nausea, feeling hot, abnormal taste, and warmth, burning or pain local to the injection site.
General precautions should be taken in patients who are pregnant or breastfeeding, or who have a history of allergic reaction to contrast media, bronchial asthma or an allergic respiratory disorder. |
| Indications and Usage |
For diagnostic use only. Indicated for adults and children age 2 and over for contrast enhancement during cranial and spinal MRI, and for contrast-enhanced magnetic resonance angiography (CE-MRA). Gadobutrol is particularly suited for the detection of very small lesions and for the visualization of tumors that do not readily take up contrast media. It may be a desired agent when the exclusion or demonstration of an additional pathology may influence the choice of therapy or patient management. It may also be suitable for perfusion studies in the diagnosis of stroke, detection of focal cerebral ischemia, and in studies of tumor perfusion. |
| Marketing Status |
approved |
| ATC Code |
V08CA09 |
| DrugBank ID |
DB06703
|
| KEGG ID |
D07420
|
| MeSH ID |
C090600
|
| PubChem ID |
189914
|
| TTD Drug ID |
D0P1IZ
|
| NDC Product Code |
50419-325; 57884-0035; 70436-122; 65219-281 |
| UNII |
1BJ477IO2L
|
| Synonyms |
gadobutrol | Gadovist | gadolinium-DO3A-butriol | Gd-DO3A-butriol |
