Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Gadodiamide
Drug ID BADD_D00985
Description Gadodiamide is a paramagnetic gadolinium-based contrast agent (GBCA) that is used in MR imaging procedures to assist in the visualization of blood vessels. It is intravenously injected and is commonly marketed under the trade name Omniscan.
Indications and Usage For intravenous use in MRI to visualize lesions with abnormal vascularity (or those thought to cause abnormalities in the blood-brain barrier) in the brain (intracranial lesions), spine, and associated tissues.
Marketing Status approved; investigational
ATC Code V08CA03
DrugBank ID DB00225
KEGG ID D04284
MeSH ID C064925
PubChem ID 60754
TTD Drug ID D03EEH
NDC Product Code 0407-0691; 0407-0690; 71806-069
UNII 84F6U3J2R6
Synonyms gadodiamide | Gd-DTPA bis-(methylamide) | Gd-DTPA-BMA | Omniscan | Omniscan Unique Softpack
Chemical Information
Molecular Formula C16H28GdN5O9
CAS Registry Number 122795-43-1
SMILES CNC(=O)CN(CCN(CCN(CC(=O)NC)CC(=O)[O-])CC(=O)[O-])CC(=O)[O-].O.[Gd+3]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Disturbance in attention19.21.02.002; 17.03.03.0010.014227%
Dry mouth07.06.01.002--
Dry skin23.03.03.0010.014227%
Dysgeusia07.14.03.001; 17.02.07.003--
Dysphonia22.12.03.006; 19.19.03.002; 17.02.08.0040.010670%
Dysphoria19.04.02.0040.007113%Not Available
Dyspnoea02.11.05.003; 22.02.01.0040.148670%
Eczema23.03.04.0060.007113%
Electrolyte imbalance14.05.01.0020.007113%Not Available
Encephalopathy17.13.02.0010.010670%
Eructation07.01.02.003--
Erythema23.03.06.0010.155783%Not Available
Eye pain06.08.03.0020.019206%
Eyelid oedema10.01.05.001; 06.04.04.004; 23.04.01.0030.021340%Not Available
Face oedema23.04.01.004; 10.01.05.002; 08.01.07.0030.014227%
Fatigue08.01.01.002--
Feeling abnormal08.01.09.0140.024897%Not Available
Feeling cold08.01.09.0080.007113%Not Available
Feeling hot08.01.09.0090.034856%Not Available
Fibrosis08.03.01.0010.017783%Not Available
Flushing23.06.05.003; 24.03.01.002; 08.01.03.0250.041969%
Generalised tonic-clonic seizure17.12.01.0020.007113%Not Available
Headache17.14.01.001--
Hepatic function abnormal09.01.02.001--Not Available
Hyperaemia24.03.02.0020.019206%Not Available
Hyperhidrosis23.02.03.004; 08.01.03.0280.054773%
Hyperkeratosis23.01.01.0010.007113%
Hypersensitivity10.01.03.0030.054062%
Hypertension24.08.02.001--
Hypoaesthesia23.03.03.081; 17.02.06.0230.021340%Not Available
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