| Pharmaceutical Information |
| Drug Name |
Gadoxetate disodium |
| Drug ID |
BADD_D00995 |
| Description |
Gadoxetic acid (gadoxetate) is a paramagnetic gadolinium-containing contrast agent in which its salt form, gadoxetate disodium, is used for intravenous injection. Ethoxybenzyl diethylenetriaminepentaacetic acid is the moiety that chelates with a gadolinium ion and forms a stable complex with it to make up the drug. It is marketed by Bayer HealthCare Pharmaceuticals and FDA approved on July 3, 2008. |
| Indications and Usage |
Gadoxetate is used as a contrast medium for magnetic resonance imaging (MRI) to detect and characterize lesions in the liver. |
| Marketing Status |
approved |
| ATC Code |
V08CA10 |
| DrugBank ID |
DB08884
|
| KEGG ID |
D04288
|
| MeSH ID |
C073590
|
| PubChem ID |
9961939
|
| TTD Drug ID |
D0X2FT
|
| NDC Product Code |
61662-0020; 50419-320 |
| UNII |
HOY74VZE0M
|
| Synonyms |
gadolinium ethoxybenzyl DTPA | Gd-EOB-DTPA | gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid | gadoxetic acid | gadoxetic acid disodium | gadoxetate disodium | disodium gadoxetate | gadolinium (4S)-4-(4-ethoxybenzyl)-3,6,9-tris(carboxylatomethyl)-3,6,9-triazaundecanoic acid disodium salt | Eovist | Primovist |
|
| Chemical Information |
| Molecular Formula |
C23H28GdN3Na2O11 |
| CAS Registry Number |
135326-22-6 |
| SMILES |
CCOC1=CC=C(C=C1)CC(CN(CCN(CC(=O)[O-])CC(=O)[O-])CC(=O)[O-])N(CC(=O)[O-])CC(=O)[O
-].[Na+].[Na+].[Gd+3] |
| Chemical Structure |
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| ADRs Induced by Drug |
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*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
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| ADR Term |
ADReCS ID |
ADR Frequency (FAERS)
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ADR Severity Grade (FAERS)
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ADR Severity Grade (CTCAE)
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| Tachycardia | 02.03.02.007 | - | - | Not Available | | Urticaria | 23.04.02.001; 10.01.06.001 | - | - | | | Vertigo | 17.02.12.002; 04.04.01.003 | - | - | | | Vomiting | 07.01.07.003 | - | - | | | Feeding disorder | 19.09.01.003; 14.03.02.003 | - | - | Not Available |
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