Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Gefitinib
Drug ID BADD_D01008
Description Gefitinib (originally coded ZD1839) is a drug used in the treatment of certain types of cancer. Acting in a similar manner to erlotinib (marketed as Tarceva), gefitinib selectively targets the mutant proteins in malignant cells. It is marketed by AstraZeneca under the trade name Iressa.
Indications and Usage For the continued treatment of patients with locally advanced or metastatic non-small cell lung cancer after failure of either platinum-based or docetaxel chemotherapies.
Marketing Status approved; investigational
ATC Code L01EB01
DrugBank ID DB00317
KEGG ID D01977
MeSH ID D000077156
PubChem ID 123631
TTD Drug ID D09XZB
NDC Product Code 61200-002; 65344-0029; 54245-1359; 60505-4512; 69339-168; 50742-366; 67184-0531; 0310-0482; 53104-7700; 63850-8070; 0480-4053; 68554-0060; 73377-128; 54893-0036
UNII S65743JHBS
Synonyms Gefitinib | N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-(4-morpholinyl)propoxy)-4-quinazolinamide | Iressa | ZD1839 | ZD 1839
Chemical Information
Molecular Formula C22H24ClFN4O3
CAS Registry Number 184475-35-2
SMILES COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Weight decreased13.15.01.005--
Growth of eyelashes06.06.04.007--Not Available
Onychoclasis23.02.05.0050.000112%Not Available
General physical health deterioration08.01.03.0180.000336%Not Available
Lacunar infarction24.04.06.009; 17.08.01.0160.000112%Not Available
Malignant neoplasm progression16.16.01.0050.016118%Not Available
Lymphatic disorder01.09.01.003--Not Available
Drug tolerance08.06.01.0030.000112%Not Available
Protein urine present13.13.02.006--Not Available
Skin swelling23.03.03.0390.000112%Not Available
Haemorrhage24.07.01.002--Not Available
Pulmonary mass22.02.07.0040.000168%Not Available
Pneumatosis intestinalis07.11.01.0430.000224%Not Available
Breast cancer female21.05.01.011; 16.10.01.0040.000112%Not Available
Cognitive disorder19.21.02.001; 17.03.03.0030.000168%
Cancer pain16.32.03.004--Not Available
Lung neoplasm malignant22.08.01.001; 16.19.02.0010.000224%Not Available
Angiopathy24.03.02.007--Not Available
Metastases to central nervous system16.22.02.004; 17.02.10.0130.002462%Not Available
Epidermal necrosis23.03.03.035--Not Available
Skin toxicity23.03.03.032; 12.03.01.0200.000224%Not Available
Drug resistance08.06.01.0050.007723%Not Available
Cardiac disorder02.11.01.003--Not Available
Haematotoxicity12.03.01.025; 01.05.01.0070.000112%Not Available
Infestation11.09.01.001; 23.11.01.002--Not Available
Ischaemia24.04.02.004--Not Available
Malnutrition14.03.02.004--Not Available
Mediastinal disorder22.09.03.001--Not Available
Neoplasm progression16.16.02.0050.000224%Not Available
Decreased appetite14.03.01.005; 08.01.09.0280.001231%
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ADReCS-Target
Drug Name ADR Term Target
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