Drug Name |
Gemcitabine hydrochloride |
Drug ID |
BADD_D01010 |
Description |
Gemcitabine is a nucleoside analog and a chemotherapeutic agent. It was originally investigated for its antiviral effects, but it is now used as an anticancer therapy for various cancers.[A233135] Gemcitabine is a cytidine analog with two fluorine atoms replacing the hydroxyl on the ribose.[A233145] As a prodrug, gemcitabine is transformed into its active metabolites that work by replacing the building blocks of nucleic acids during DNA elongation, arresting tumour growth and promoting apoptosis of malignant cells.[L32960] The structure, metabolism, and mechanism of action of gemcitabine are similar to [cytarabine], but gemcitabine has a wider spectrum of antitumour activity.[A233140]
Gemcitabine is marketed as Gemzar and it is available as intravenous injection. It is approved by the FDA to treat advanced ovarian cancer in combination with [carboplatin], metastatic breast cancer in combination with [paclitaxel], non-small cell lung cancer in combination with [cisplatin], and pancreatic cancer as monotherapy.[L32950] It is also being investigated in other cancer and tumour types. |
Indications and Usage |
Gemcitabine is indicated for the treatment of advanced ovarian cancer that has relapsed at least 6 months after completion of platinum-based therapy; metastatic ovarian cancer; inoperable, locally advanced (Stage IIIA or IIIB), or metastatic (Stage IV) non-small cell lung cancer; and locally advanced (nonresectable Stage II or Stage III) or metastatic (Stage IV) adenocarcinoma of the pancreas. |
Marketing Status |
Prescription; Discontinued |
ATC Code |
L01BC05 |
DrugBank ID |
DB00441
|
KEGG ID |
D01155
|
MeSH ID |
C056507
|
PubChem ID |
60749
|
TTD Drug ID |
D03UVS
|
NDC Product Code |
25021-234; 54893-0006; 70860-204; 66529-0011; 54245-1091; 68083-149; 13808-501; 63759-7001; 16714-930; 16729-117; 53104-7689; 16729-118; 65129-1091; 67457-616; 71288-114; 68083-148; 72485-222; 70860-205; 63592-4075; 71288-113; 67457-617; 25021-235; 55111-807; 62128-0383; 16729-092; 66529-0004; 72485-223; 71288-117; 58623-0019; 16714-909; 72485-221; 68554-0028; 67457-618 |
Synonyms |
gemcitabine | 2',2'-difluoro-2'-deoxycytidine | gemicitabine | 2'-deoxy-2'-difluorocytidine | dFdCyd | 2',2'-DFDC | 2',2'-difluorodeoxycytidine | gemcitabine hydrochloride | LY 188011 | LY-188011 | gemcitabine, (beta-D-threo-pentafuranosyl)-isomer | gemcitabine, (D-threo-pentafuranosyl)-isomer | Gemzar | 2'-deoxy-2',2''-difluorocytidine-5'-O-monophosphate | gemcitabine, (alpha-D-threo-pentofuranosyl)-isomer |