Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Gemfibrozil
Drug ID BADD_D01012
Description Gemfibrozil is a fibric acid agent, similar to [clofibrate], used to treat Type IIb, IV, and V hyperlipidemias.[A185777,L8525] Gemfibrozil is not a first line treatment and is prescribed to patients who have not responded adequately to weight loss, diet, exercise, and other medications.[L8525] Gemfibrozil was granted FDA approval on 21 December 1981.[L8525]
Indications and Usage Gemfibrozil is indicated to treat patients with Types IV and V hyperlipidemia who have elevated serum triglycerides (usually above 2000mg/dL), elevated VLDL cholesterol, fasting chylomicrons, are at risk of developing pancreatitis, and do not adequately respond to dietary restrictions.[L8525] Gemfibrozil is also indicated to reduce the risk of developing coronary heart disease in patients with Type IIb hyperlipidemia without history or symptoms of coronary heart disease; who do not adequately respond to weight loss, diet, exercise, and other medications; and have low HDL, raised LDL, and raised triglycerides.[L8525]
Marketing Status approved
ATC Code C10AB04
DrugBank ID DB01241
KEGG ID D00334
MeSH ID D015248
PubChem ID 3463
TTD Drug ID D05VIX
NDC Product Code 15440-1025; 51655-143; 57237-163; 65862-624; 71205-169; 71335-0899; 75834-131; 62991-2883; 65862-424; 50090-5808; 53002-2068; 55700-493; 68071-4053; 71610-601; 0615-8354; 43063-921; 50268-350; 68788-7964; 70934-255; 71335-0971; 61919-967; 68071-2296; 71610-107; 65691-0089; 24658-260; 43602-452; 71335-0051; 16714-101; 70518-1563; 71335-2025; 49452-3263; 16571-784; 63187-146; 63187-772; 70771-1431; 71335-0515; 76282-225; 0071-0737; 60687-224; 68382-553; 71209-008; 71335-1902; 72578-066; 71335-1996; 71610-200; 66651-905; 31722-128; 42806-260; 69097-821; 72865-186; 43063-745; 53002-1068
UNII Q8X02027X3
Synonyms Gemfibrozil | Gemfibrosil | Ausgem | Bolutol | Chem mart Gemfibrozil | CI-719 | CI 719 | CI719 | DBL Gemfibrozil | Decrelip | Gemfi 1A Pharma | Gemfibrozilo Bayvit | Bayvit, Gemfibrozilo | Gemfibrozilo Bexal | Gemfibrozilo Ur | Gemhexal | Gen-Gemfibrozil | Gen Gemfibrozil | GenGemfibrozil | GenRX Gemfibrozil | Gemfibrozil, GenRX | Healthsense Gemfibrozil | Gemfibrozil, Healthsense | Jezil | Lipazil | Lipox Gemfi | Litarek | Lopid | Lipur | Lopid R | Novo-Gemfibrozil | Novo Gemfibrozil | Nu-Gemfibrozil | Nu Gemfibrozil | NuGemfibrozil | Pilder | PMS-Gemfibrozil | PMS Gemfibrozil | SBPA Gemfibrozil | Gemfibrozil, SBPA | Terry White Chemists Gemfibrozil | Trialmin | Apo-Gemfibrozil | Apo Gemfibrozil | ApoGemfibrozil
Chemical Information
Molecular Formula C15H22O3
CAS Registry Number 25812-30-0
SMILES CC1=CC(=C(C=C1)C)OCCCC(C)(C)C(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.0010.000365%Not Available
Abdominal pain07.01.05.0020.000419%
Abdominal pain upper07.01.05.003--
Alanine aminotransferase increased13.03.04.005--
Alopecia23.02.02.001--
Anaemia01.03.02.0010.000236%
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Angioedema23.04.01.001; 10.01.05.009; 22.04.02.0080.000419%Not Available
Appendicitis11.01.07.001; 07.19.01.001--
Arthralgia15.01.02.001--
Aspartate aminotransferase increased13.03.04.011--
Asthenia08.01.01.0010.000655%Not Available
Atrial fibrillation02.03.03.002--
Blood bilirubin increased13.03.04.018--
Blood creatine phosphokinase increased13.04.01.001--
Cataract06.06.01.001--
Cerebral haemorrhage24.07.04.001; 17.08.01.003--Not Available
Chest pain22.12.02.003; 08.01.08.002; 02.02.02.0110.000290%Not Available
Cholecystitis09.03.01.001--
Cholelithiasis09.03.01.0020.000107%Not Available
Chromaturia20.02.01.0020.000161%
Colitis07.08.01.001--
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.001--
Cough22.02.03.001--
Depression19.15.01.001--
Dermatitis23.03.04.002--Not Available
Dermatitis exfoliative23.03.07.001; 10.01.01.004--
Diarrhoea07.02.01.001--
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