| Pharmaceutical Information |
| Drug Name |
Gentamicin |
| Drug ID |
BADD_D01016 |
| Description |
Gentamicin is a bactericidal aminoglycoside that was discovered and isolated from _Micromonospora purpurea_ in 1963.[A234349] It is one of the most frequently prescribed aminoglycosides due to its spectrum of activity, low cost, and availability.[A234339,A234354] Gentamicin is effective against both gram-positive and gram-negative organisms but is particularly useful for the treatment of severe gram-negative infections including those caused by _Pseudomonas aeruginosa_.[A233325,A234359,A234364] There is the added benefit of synergy when gentamicin is co-administered with other antibacterials such as beta-lactams.[A234364] This synergistic activity is not only important for the treatment of complex infections, but can also contribute to dose optimization and reduced adverse effects.[A234359,A234364]
Although gentamicin is well-established and may be used in a variety of clinical applications, it is also associated with severe adverse effects including nephrotoxicity and ototoxicity which may limit its use.[A234369] |
| Indications and Usage |
Not Available |
| Marketing Status |
approved; vet_approved |
| ATC Code |
D06AX07; J01GB03; S01AA11; S02AA14; S03AA06 |
| DrugBank ID |
DB00798
|
| KEGG ID |
D08013
|
| MeSH ID |
D005839
|
| PubChem ID |
3467
|
| TTD Drug ID |
D0L9UU
|
| NDC Product Code |
63323-173; 0143-9128; 0143-9129; 51662-1508 |
| UNII |
T6Z9V48IKG
|
| Synonyms |
Gentamicins | Gentamycins | Garamycin | Gentacycol | Gentamicin Sulfate | Sulfate, Gentamicin | Gentamicin Sulfate (USP) | Gentavet | Genticin | G-Myticin | G Myticin | GMyticin | Gentamicin | Gentamycin |
|
| Chemical Information |
| Molecular Formula |
C21H43N5O7 |
| CAS Registry Number |
1403-66-3 |
| SMILES |
CC(C1CCC(C(O1)OC2C(CC(C(C2O)OC3C(C(C(CO3)(C)O)NC)O)N)N)N)NC |
| Chemical Structure |
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| ADRs Induced by Drug |
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