| Pharmaceutical Information |
| Drug Name |
Gentamicin sulfate |
| Drug ID |
BADD_D01017 |
| Description |
Gentamicin is a bactericidal aminoglycoside that was discovered and isolated from _Micromonospora purpurea_ in 1963.[A234349] It is one of the most frequently prescribed aminoglycosides due to its spectrum of activity, low cost, and availability.[A234339,A234354] Gentamicin is effective against both gram-positive and gram-negative organisms but is particularly useful for the treatment of severe gram-negative infections including those caused by _Pseudomonas aeruginosa_.[A233325,A234359,A234364] There is the added benefit of synergy when gentamicin is co-administered with other antibacterials such as beta-lactams.[A234364] This synergistic activity is not only important for the treatment of complex infections, but can also contribute to dose optimization and reduced adverse effects.[A234359,A234364]
Although gentamicin is well-established and may be used in a variety of clinical applications, it is also associated with severe adverse effects including nephrotoxicity and ototoxicity which may limit its use.[A234369] |
| Indications and Usage |
Not Available |
| Marketing Status |
approved; vet_approved |
| ATC Code |
J01GB03; S03AA06; S01AA11; S02AA14; D06AX07 |
| DrugBank ID |
DB00798
|
| KEGG ID |
D01063
|
| MeSH ID |
D005839
|
| PubChem ID |
44134730
|
| TTD Drug ID |
D0L9UU
|
| NDC Product Code |
76420-137; 61919-106; 0404-9865; 0404-9866; 68788-7336; 70518-1323; 51927-1610; 67630-0003; 50090-0569; 0338-0509; 71205-333; 38779-0632; 48866-8256; 17478-284; 24208-580; 45802-046; 45802-056; 45865-672; 63187-764; 0409-1207; 55154-2392; 60758-188; 61919-918; 66267-971; 51552-0775; 50090-2333; 0338-0503; 17478-283; 61314-633; 63187-873; 70518-3628; 71205-560; 42513-0008; 53002-9292; 51662-1597; 63187-163; 63323-010; 0713-0683; 76420-254; 51927-0252; 53002-9290; 0338-0505; 0338-0511; 0713-0682; 62991-1072; 63187-560; 71872-7216; 60592-301; 0338-0507 |
| UNII |
8X7386QRLV
|
| Synonyms |
Gentamicins | Gentamycins | Garamycin | Gentacycol | Gentamicin Sulfate | Sulfate, Gentamicin | Gentamicin Sulfate (USP) | Gentavet | Genticin | G-Myticin | G Myticin | GMyticin | Gentamicin | Gentamycin |
|
| Chemical Information |
| Molecular Formula |
C21H45N5O11S |
| CAS Registry Number |
1403-66-3 |
| SMILES |
CC(C1CCC(C(O1)OC2C(CC(C(C2O)OC3C(C(C(CO3)(C)O)NC)O)N)N)N)NC.OS(=O)(=O)O |
| Chemical Structure |
|
|
| ADRs Induced by Drug |
|
|
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
|
|
|
