Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Glutamine
Drug ID BADD_D01029
Description A non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. It is synthesized from glutamic acid and ammonia. It is the principal carrier of nitrogen in the body and is an important energy source for many cells. An oral formulation of L-glutamine was approved by the FDA in July 2017 for use in sickle cell disease [L892]. This oral formulation is marketed under the tradename Endari by Emmaus Medical.
Indications and Usage Used for nutritional supplementation, also for treating dietary shortage or imbalance. Used to reduce the acute complications of sickle cell disease in adult and pediatric patients 5 years of age and older [FDA Label].
Marketing Status approved; investigational; nutraceutical
ATC Code A16AA03
DrugBank ID DB00130
KEGG ID D00015
MeSH ID D005973
PubChem ID 5961
TTD Drug ID D01JIA
NDC Product Code 58159-080; 42457-420; 51552-0285
UNII 0RH81L854J
Synonyms Glutamine | L-Glutamine | L Glutamine | D-Glutamine | D Glutamine
Chemical Information
Molecular Formula C5H10N2O3
CAS Registry Number 56-85-9
SMILES C(CC(=O)N)C(C(=O)O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.0020.021993%
Arthralgia15.01.02.001--
Asthenia08.01.01.001--Not Available
Back pain15.03.04.005--
Body temperature increased13.15.01.001--Not Available
Breast pain21.05.05.003--
Chest pain22.12.02.003; 08.01.08.002; 02.02.02.0110.036655%Not Available
Chills15.05.03.016; 08.01.09.001--
Constipation07.02.02.0010.016818%
Crohn's disease10.02.01.005; 07.08.01.015--Not Available
Death08.04.01.0010.008625%
Dehydration14.05.05.001--
Depression19.15.01.001--
Dermatitis23.03.04.002--Not Available
Discomfort08.01.08.003--Not Available
Dizziness02.11.04.006; 24.06.02.007; 17.02.05.003--
Dry mouth07.06.01.002--
Dyspnoea22.02.01.004; 02.11.05.0030.009487%
Ear disorder04.03.01.001--Not Available
Face oedema23.04.01.004; 10.01.05.002; 08.01.07.003--
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014--Not Available
Flatulence07.01.04.002--
Fungal infection11.03.05.001--Not Available
Gastric ulcer07.04.03.002--
Gastrointestinal fistula07.11.05.001--
Gastrointestinal pain07.01.05.005--
Generalised oedema08.01.07.004; 14.05.06.007--
Haemorrhoids24.10.02.002; 07.15.03.001--
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ADReCS-Target
Drug Name ADR Term Target
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