Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Glyburide
Drug ID BADD_D01030
Description Glyburide is a second generation sulfonylurea used to treat patients with diabetes mellitus type II.[L8123] It is typically given to patients who cannot be managed with the standard first line therapy, [metformin].[L8123] Glyburide stimulates insulin secretion through the closure of ATP-sensitive potassium channels on beta cells, raising intracellular potassium and calcium ion concentrations.[A183617] Glyburide was granted FDA approval on 1 May 1984.[L8117] A formulation with metformin was granted FDA approval on on 31 July 2000.[L8120]
Indications and Usage Glyburide is indicated alone or as part of combination product with metformin, as an adjunct to diet and exercise, to improve glycemic control in adults with type 2 diabetes mellitus.[L8120,L8123]
Marketing Status approved
ATC Code A10BB01
DrugBank ID DB01016
KEGG ID D00336
MeSH ID D005905
PubChem ID 3488
TTD Drug ID D05LYX
NDC Product Code 76333-154; 76333-155; 65691-0041; 23155-058; 0093-8034; 50090-0495; 51655-492; 65841-833; 68071-5217; 68382-658; 71209-011; 72241-039; 12579-056; 62147-0002; 50090-5776; 55700-725; 62135-584; 63187-848; 68071-3452; 70518-1646; 70934-690; 71335-0150; 12828-0066; 0093-8342; 0093-9477; 50090-6196; 62135-583; 62135-585; 68071-2189; 68788-8343; 71335-0069; 71209-009; 49452-3355; 0093-8036; 0093-9364; 53002-4170; 65841-834; 68382-656; 72241-040; 75834-204; 76333-156; 23155-056; 0009-0352; 0009-3449; 63187-659; 65841-832; 70518-3504; 65862-318; 68382-657; 75834-202; 43898-0001; 0093-8344; 0093-9433; 61919-378; 68071-2589; 23155-057; 68788-7970; 70518-1201; 46438-0059; 0009-0341; 63187-667; 70518-1513; 70934-855; 71209-010; 72241-038; 75834-203; 12579-054; 12579-055; 0093-8035; 0093-8343; 51655-659
UNII SX6K58TVWC
Synonyms Glyburide | Glybenclamide | Glibenclamide | Diabeta | Euglucon 5 | Neogluconin | HB-419 | HB 419 | HB419 | HB-420 | HB 420 | HB420 | Maninil | Micronase | Daonil | Euglucon N
Chemical Information
Molecular Formula C23H28ClN3O5S
CAS Registry Number 10238-21-8
SMILES COC1=C(C=C(C=C1)Cl)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCCCC3
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Depressed level of consciousness17.02.04.0020.000152%
Dermatitis23.03.04.002--Not Available
Dermatitis bullous23.03.01.002--
Diarrhoea07.02.01.0010.000445%
Diplopia17.17.01.005; 06.02.06.002--Not Available
Discomfort08.01.08.003--Not Available
Drug abuse19.07.06.0100.000101%Not Available
Drug eruption23.03.05.001; 10.01.01.005; 08.01.06.015--Not Available
Drug hypersensitivity10.01.01.0010.002235%Not Available
Dyspepsia07.01.02.001--
Dyspnoea02.11.05.003; 22.02.01.004--
Encephalopathy17.13.02.0010.000101%
Eosinophilia01.02.04.001--
Erythema23.03.06.001--Not Available
Erythropenia01.07.02.001--Not Available
Eye disorder06.08.03.001--Not Available
Feeling abnormal08.01.09.014--Not Available
Gait disturbance15.03.05.013; 17.02.05.016; 08.01.02.0020.000101%
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal pain07.01.05.005--
Granulomatous liver disease09.01.07.001--Not Available
Haemolytic anaemia01.06.03.002--Not Available
Headache17.14.01.001--
Hepatic failure09.01.03.002--
Hepatic function abnormal09.01.02.001--Not Available
Hepatitis09.01.07.004--Not Available
Hepatitis cholestatic09.01.01.002--Not Available
Hyperbilirubinaemia14.11.01.010; 09.01.01.003; 01.06.04.003--Not Available
Hyperglycaemia14.06.02.002; 05.06.02.002--
Hyperhidrosis23.02.03.004; 08.01.03.028--
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ADReCS-Target
Drug Name ADR Term Target
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