Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Granisetron
Drug ID BADD_D01040
Description A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
Indications and Usage For the prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer therapy (including high dose cisplatin), postoperation, and radiation (including total body irradiation and daily fractionated abdominal radiation).
Marketing Status approved; investigational
ATC Code A04AA02
DrugBank ID DB00889
KEGG ID D04370
MeSH ID D017829
PubChem ID 5284566
TTD Drug ID D0J5KF
NDC Product Code 14778-0202; 47426-101; 63850-7308; 42747-726; 53104-7609; 55111-841; 55718-117; 54871-1091
UNII WZG3J2MCOL
Synonyms Granisetron | 1-Methyl-N-(endo-9-Methyl-9-Azabicyclo(3.3.1)non-3-yl)-1H-Indazole-3-Carboxamide | Kytril | BRL-43694A | BRL 43694A | BRL43694A | BRL-43694 | BRL 43694 | BRL43694 | Granisetron Hydrochloride | Hydrochloride, Granisetron | Granisetron Monohydrochloride | Monohydrochloride, Granisetron
Chemical Information
Molecular Formula C18H24N4O
CAS Registry Number 109889-09-0
SMILES CN1C2CCCC1CC(C2)NC(=O)C3=NN(C4=CC=CC=C43)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Gamma-glutamyltransferase increased13.03.04.024--
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.001--Not Available
Gastrointestinal pain07.01.05.005--
Generalised oedema08.01.07.004; 14.05.06.007--
Generalised tonic-clonic seizure17.12.01.002--Not Available
Haematoma24.07.01.0010.007023%
Headache17.14.01.001--
Hepatocellular injury09.01.07.008--Not Available
Hiccups07.01.06.009; 22.12.01.001--
Hyperbilirubinaemia14.11.01.010; 09.01.01.003; 01.06.04.003--Not Available
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hyperphosphataemia14.04.03.007--
Hypersensitivity10.01.03.0030.017556%
Hypertension24.08.02.001--
Hypokalaemia14.05.03.002--
Hyponatraemia14.05.04.002--
Hypotension24.06.03.002--
Ileus07.13.01.001--
Infection11.01.08.002--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Instillation site pain12.07.01.008; 08.02.01.008--Not Available
Jaundice01.06.04.004; 23.03.03.030; 09.01.01.004--Not Available
Leukocytosis01.02.01.002--
Leukopenia01.02.02.001--Not Available
Liver function test abnormal13.03.04.030--Not Available
Loss of consciousness17.02.04.004--Not Available
Malaise08.01.01.0030.054735%
Melaena24.07.02.013; 07.12.02.004--Not Available
Migraine24.03.05.003; 17.14.02.0010.008055%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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