Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Guanfacine
Drug ID BADD_D01046
Description Guanfacine, or BS 100-141,[A189838,A189841] is a selective alpha-A2 adrenergic receptor agonist initially indicated for the treatment of hypertension[L11274] but is now indicated as an extended release tablet for the treatment of ADHD.[L11277] Guanfacine was first described in the literature in 1974.[A189841] Guanfacine was granted FDA approval on 27 October 1986.[L11274]
Indications and Usage Guanfacine is indicated alone or as an adjunct with stimulants to treat ADHD.[L11277]
Marketing Status approved; investigational
ATC Code C02AC02
DrugBank ID DB01018
KEGG ID D08031
MeSH ID D016316
PubChem ID 3519
TTD Drug ID Not Available
NDC Product Code 0591-0444; 0591-0453; 27241-243; 42291-326; 60505-3928; 62135-728; 70436-040; 72162-2029; 16714-191; 16714-192; 42806-296; 60429-960; 70436-042; 71205-946; 0228-2855; 53746-711; 60505-3929; 60505-3930; 63629-1102; 63629-8203; 70518-1369; 71205-945; 63304-927; 65162-713; 70436-039; 70518-2771; 24658-730; 24979-198; 0228-2851; 63629-1105; 16714-190; 16714-193; 24979-538; 60429-961; 62135-727; 63629-8161; 70518-1371; 71205-947; 24979-199; 24979-536; 50268-374; 63304-926; 24658-731; 42806-048; 53746-713; 54092-515; 60429-962; 60429-963; 60505-3927; 63629-1103; 65162-711; 70436-041; 71335-9750; 72162-2030; 42291-327; 0228-2850; 0228-2853; 54092-517; 63187-302; 63304-924; 63304-925; 71205-944; 24979-534; 27241-242; 42291-325; 50090-5991; 54092-519; 63629-1104; 68094-065; 70518-0793; 0904-7140; 24979-533; 42291-324; 50090-6073; 50090-6493; 54092-513
UNII 30OMY4G3MK
Synonyms Guanfacine | Tenex | Guanfacine Hydrochloride | Hydrochloride, Guanfacine | Guanfacine Monohydrochloride | Monohydrochloride, Guanfacine | Lon798 | BS-100-141 | BS 100 141 | BS100141 | Estulic
Chemical Information
Molecular Formula C9H9Cl2N3O
CAS Registry Number 29110-47-2
SMILES C1=CC(=C(C(=C1)Cl)CC(=O)N=C(N)N)Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Cytopenia01.03.03.0120.000173%Not Available
Treatment failure08.06.01.0170.000173%Not Available
Adverse reaction08.06.01.0180.000259%Not Available
Acute kidney injury20.01.03.016--
Posterior reversible encephalopathy syndrome17.13.02.0070.000173%
Coeliac disease14.02.01.007; 10.04.04.012; 07.17.01.0080.000173%Not Available
Impulsive behaviour19.18.01.0010.000848%Not Available
Regressive behaviour19.01.01.0040.000173%Not Available
Disturbance in social behaviour19.05.01.0180.001349%Not Available
Attention deficit hyperactivity disorder19.21.04.0040.000381%Not Available
Gait inability17.02.05.069; 08.01.02.0110.000173%Not Available
Growth failure15.03.05.015; 14.03.02.030; 05.03.02.0060.000173%Not Available
Psychotic symptom19.03.01.0120.000259%Not Available
Therapeutic product effect decreased08.06.01.0500.001176%Not Available
Therapeutic product effect increased08.06.01.0530.000588%Not Available
Therapeutic response shortened08.06.01.062--Not Available
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