Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Guanidine
Drug ID BADD_D01048
Description A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.
Indications and Usage For the reduction of the symptoms of muscle weakness and easy fatigability associated with the myasthenic syndrome of Eaton-Lambert. It is not indicated for treating myasthenia gravis.
Marketing Status approved
ATC Code Not Available
DrugBank ID DB00536
KEGG ID D11626
MeSH ID D019791
PubChem ID 3520
TTD Drug ID D0F7NZ
NDC Product Code Not Available
UNII JU58VJ6Y3B
Synonyms Guanidine | Guanidinium | Guanidine Monohydrate | Monohydrate, Guanidine | Guanidine Monohydrobromide | Monohydrobromide, Guanidine | Guanidine Monohydroiodine | Monohydroiodine, Guanidine | Guanidine Sulfite (1:1) | Guanidine Phosphate | Phosphate, Guanidine | Guanidine Sulfate | Sulfate, Guanidine | Guanidine Sulfate (1:1) | Guanidine Sulfate (2:1) | Guanidine Hydrochloride | Hydrochloride, Guanidine | Guanidinium Chloride | Chloride, Guanidinium | Guanidium Chloride | Chloride, Guanidium | Guanidine Monohydrochloride | Monohydrochloride, Guanidine | Guanidine Nitrate | Nitrate, Guanidine
Chemical Information
Molecular Formula CH5N3
CAS Registry Number 113-00-8
SMILES C(=N)(N)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Anaemia01.03.02.001--
Ataxia17.02.02.001; 08.01.02.004--
Atrial fibrillation02.03.03.002--
Azotaemia20.01.01.001--Not Available
Body temperature increased13.15.01.001--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.001--
Dizziness02.11.04.006; 24.06.02.007; 17.02.05.003--
Dry mouth07.06.01.002--
Ecchymosis24.07.06.002; 23.06.01.001; 01.01.03.001--Not Available
Feeling abnormal08.01.09.014--Not Available
Feeling cold08.01.09.008--Not Available
Feeling jittery08.01.09.016--Not Available
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Folliculitis11.02.01.053; 23.11.04.003--
Hallucination19.10.04.003--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypotension24.06.03.002--
Irritability19.04.02.013; 08.01.03.011--
Leukopenia01.02.02.001--Not Available
Liver function test abnormal13.03.04.030--Not Available
Mood swings19.04.03.001--Not Available
Nausea07.01.07.001--
Nervousness19.06.02.003--Not Available
Palpitations02.11.04.012--
Paraesthesia17.02.06.005; 23.03.03.094--
Petechiae24.07.06.004; 23.06.01.003; 01.01.03.002--Not Available
Purpura24.07.06.005; 23.06.01.004; 01.01.04.003--
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