Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Hemin
Drug ID BADD_D01058
Description Hemin (trade name Panhematin) is an iron-containing porphyrin. More specifically, it is protoporphyrin IX containing a ferric iron ion (heme B) with a chloride ligand.
Indications and Usage Used in the management of porphyria attacks, particularly in acute intermittent porphyria.
Marketing Status approved; investigational
ATC Code B06AB01
DrugBank ID DB03404
KEGG ID D10003
MeSH ID D006427
PubChem ID 26945
TTD Drug ID D0UU1I
NDC Product Code 55292-702; 51014-7945
UNII 743LRP9S7N
Synonyms Hemin | Ferriheme Chloride | Chloride, Ferriheme | Protohemin IX | Protohemin | Chlorohemin | Ferriprotoporphyrin IX Chloride | Chloride, Ferriprotoporphyrin IX | Ferrihaem | Panhematin | Ferriprotoporphyrin IX | Hematin | Alkaline Hematin D-575 | Alkaline Hematin D 575 | Hematin D-575, Alkaline | Ferriprotoporphyrin
Chemical Information
Molecular Formula C34H32FeN4O4
CAS Registry Number 14875-96-8
SMILES CC1=C(C2=CC3=C(C(=C([N-]3)C=C4C(=C(C(=N4)C=C5C(=C(C(=N5)C=C1[N-]2)C)C=C)C)C=C)C) CCC(=O)O)CCC(=O)O.[Fe+2]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002-
Activated partial thromboplastin time prolonged13.01.02.001--
Back pain15.03.04.005-
Body temperature increased13.15.01.001--Not Available
Chest pain22.12.02.003; 08.01.08.002; 02.02.02.011-Not Available
Coagulopathy01.01.02.001--Not Available
Dyspnoea02.11.05.003; 22.02.01.004-
Extravasation08.01.03.008-Not Available
Hepatic cirrhosis09.01.04.001-Not Available
Hypersensitivity10.01.03.003-
Injection site erythema23.03.06.015; 12.07.03.001; 08.02.03.001-Not Available
Injection site extravasation12.07.03.002; 08.02.03.002-Not Available
Injection site pain08.02.03.010; 12.07.03.011-Not Available
Leukocytosis01.02.01.002--
Malaise08.01.01.003-
Migraine24.03.05.003; 17.14.02.001-Not Available
Nausea07.01.07.001-
Pain08.01.08.004-
Phlebitis24.12.03.004; 12.02.01.002-
Prothrombin level increased13.01.02.011--Not Available
Pyrexia08.05.02.003--
Seizure17.12.03.001-
Serum ferritin increased13.11.01.026--Not Available
Thrombocytopenia01.08.01.002-Not Available
Thrombosis24.01.01.006-Not Available
Vomiting07.01.07.003-
Infusion site erythema23.03.06.016; 12.07.05.009; 08.02.05.008-Not Available
Deep vein thrombosis24.01.02.003-Not Available
Injection site swelling08.02.03.017; 12.07.03.018-Not Available
Infusion site pain12.07.05.002; 08.02.05.014-Not Available
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