| Pharmaceutical Information |
| Drug Name |
Hepatolite |
| Drug ID |
BADD_D01065 |
| Description |
Technetium Tc-99m disofenin is a radiopharmaceutical agent used in hepatobiliary imaging for diagnostic purposes. It is well suited for both planar and single photon tomographic scintigraphy to quantitatively measure the function of liver, gallbladder and bile ducts and detect any anatomical changes in the hepatobliary system. It is available as an intravenous injection in a preparation kit under the name Hepatolite. Technetium Tc-99m is a metastable nuclear isomer and disofenin is an iminodiacetic acid derivative with no known pharmacologic actions at the doses recommended. However disofenin is the most commonly used iminodiacetic acid since it has a high liver to renal extraction and its hepatic uptake is not as highly dependent on serum bilirubin levels (a competitive inhibitor for liver uptake) as are other tracers from the iminodiacetic acid. |
| Indications and Usage |
Technetium Tc99m Disofenin is indicated as a hepatobiliary imaging agent. Hepatolite is indicated in the diagnosis of acute cholecystitis as well as to rule out the occurrence of acute cholecystitis in suspected patients with right upper quadrant pain, fever, jaundice, right upper quadrant tenderness and mass or rebound tenderness, but not limited to these signs and symptoms. |
| Marketing Status |
approved |
| ATC Code |
Not Available |
| DrugBank ID |
DB09164
|
| KEGG ID |
D06031
|
| MeSH ID |
D019785
|
| PubChem ID |
Not Available
|
| TTD Drug ID |
D0X9KI
|
| NDC Product Code |
Not Available |
| UNII |
Not Available
|
| Synonyms |
Technetium Tc 99m Disofenin | Technetium-99m-Disofenin | Technetium 99m Disofenin | Tc-99m Disofenin | Disofenin, Tc-99m | Tc 99m Disofenin | 99mTc-Disofenin | 99mTc Disofenin | 99m-Tc-Disofenin | 99m Tc Disofenin | Technetium-99m-Diisopropyliminodiacetic Acid | Acid, Technetium-99m-Diisopropyliminodiacetic | Technetium 99m Diisopropyliminodiacetic Acid | 99mTc-DISIDA | 99mTc DISIDA | Hepatolite |
|
| Chemical Information |
| Molecular Formula |
Not Available |
| CAS Registry Number |
Not Available |
| SMILES |
Not Available |
| Chemical Structure |
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| ADRs Induced by Drug |
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*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
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| ADR Term |
ADReCS ID |
ADR Frequency (FAERS)
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ADR Severity Grade (FAERS)
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ADR Severity Grade (CTCAE)
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| Chills | 15.05.03.016; 08.01.09.001 | - | - | | | Death | 08.04.01.001 | - | - | | | Erythema multiforme | 10.01.03.015; 23.03.01.003 | - | - | | | Nausea | 07.01.07.001 | - | - | |
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