Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Hydrocodone
Drug ID BADD_D01084
Description Hydrocodone is a synthetic opioid derivative of codeine.[T116] It is commonly used in combination with [acetaminophen] to control moderate to severe pain. Historically, hydrocodone has been used as a cough suppressant although this has largely been replaced by [dextromethorphan] in current cough and cold formulations. Hydrocodone's more potent metabolite, [hydromorphone] has also found wide use as an analgesic and is frequently used in cases of severe pain. The FDA first approved Hydrocodone for use as part of the cough suppressant syrup Hycodan in March of 1943.[L9025]
Indications and Usage Hydrocodone is indicated for the management of acute pain, sometimes in combination with [acetaminophen] or [ibuprofen], as well as the symptomatic treatment of the common cold and allergic rhinitis in combination with decongestants, antihistamines, and expectorants.[label,L7991]
Marketing Status approved; illicit; investigational
ATC Code R05DA03
DrugBank ID DB00956
KEGG ID D08045
MeSH ID D006853
PubChem ID 5284569
TTD Drug ID D0X5KF
NDC Product Code 81842-617
UNII 6YKS4Y3WQ7
Synonyms Hydrocodone | Hydrocodon | Dihydrocodeinone | Dicodid | Robidone | Hydrocodone Bitartrate | Hydrocodone Tartrate (1:1), Hydrate (2:5) | Hydrocodeinonebitartrate | Hydrocon | Codinovo | Hycodan | Hycon
Chemical Information
Molecular Formula C18H21NO3
CAS Registry Number 125-29-1
SMILES CN1CCC23C4C1CC5=C2C(=C(C=C5)OC)OC3C(=O)CC4
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Nervous system disorder17.02.10.001--Not Available
Night sweats23.02.03.006; 08.01.03.031--Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Osteoarthritis15.01.04.001--Not Available
Pain08.01.08.0040.009174%
Pain in extremity15.03.04.010--
Palpitations02.11.04.0120.000284%
Paraesthesia23.03.03.094; 17.02.06.005--
Pruritus23.03.12.0010.001648%
Rash23.03.13.001--Not Available
Respiratory depression22.02.01.010; 17.02.05.047--Not Available
Rhinorrhoea22.12.03.0210.000248%
Seizure17.12.03.001--
Skin disorder23.03.03.007--Not Available
Somnolence19.02.05.003; 17.02.04.006--
Thinking abnormal19.10.03.001; 17.02.05.0230.000073%Not Available
Thrombocytopenia01.08.01.002--Not Available
Tremor17.01.06.0020.000408%
Upper respiratory tract infection11.01.13.009; 22.07.03.011--
Urinary retention20.02.02.011--
Urinary tract infection20.08.02.001; 11.01.14.004--
Urticaria23.04.02.001; 10.01.06.0010.001028%
Vomiting07.01.07.0030.000926%
Withdrawal syndrome19.07.06.023; 08.06.02.0120.000219%Not Available
Hypoacusis04.02.01.006--
Emotional distress19.04.02.0080.007963%Not Available
General physical health deterioration08.01.03.0180.000109%Not Available
Muscle strain15.05.07.002; 12.01.07.004--Not Available
Contusion24.07.06.001; 15.03.05.007; 23.03.11.002; 12.01.06.001--
Ureteral spasm20.06.01.002--Not Available
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