| Pharmaceutical Information |
| Drug Name |
Hydrocodone bitartrate |
| Drug ID |
BADD_D01085 |
| Description |
Hydrocodone is a synthetic opioid derivative of codeine.[T116] It is commonly used in combination with [acetaminophen] to control moderate to severe pain. Historically, hydrocodone has been used as a cough suppressant although this has largely been replaced by [dextromethorphan] in current cough and cold formulations. Hydrocodone's more potent metabolite, [hydromorphone] has also found wide use as an analgesic and is frequently used in cases of severe pain. The FDA first approved Hydrocodone for use as part of the cough suppressant syrup Hycodan in March of 1943.[L9025] |
| Indications and Usage |
Hydrocodone is indicated for the management of acute pain, sometimes in combination with [acetaminophen] or [ibuprofen], as well as the symptomatic treatment of the common cold and allergic rhinitis in combination with decongestants, antihistamines, and expectorants.[label,L7991] |
| Marketing Status |
approved; illicit; investigational |
| ATC Code |
R05DA03 |
| DrugBank ID |
DB00956
|
| KEGG ID |
D03725
|
| MeSH ID |
D006853
|
| PubChem ID |
20831824
|
| TTD Drug ID |
D0X5KF
|
| NDC Product Code |
0406-1559; 47781-398; 47781-396; 47781-394; 47781-414; 59011-272; 59011-273; 47781-409; 47781-410; 38779-0764; 62991-3091; 47781-392; 47781-393; 47781-397; 59011-276; 51634-0014; 59116-4750; 47781-395; 47781-411; 59011-275; 49452-0033; 61960-9193; 61919-118; 0792-0543; 49812-0132; 67509-007; 47781-413; 61919-494; 63275-4100; 47781-412; 59011-271; 59011-274; 0406-1582; 51552-0677; 59116-4751; 82393-123; 59011-277 |
| UNII |
NO70W886KK
|
| Synonyms |
Hydrocodone | Hydrocodon | Dihydrocodeinone | Dicodid | Robidone | Hydrocodone Bitartrate | Hydrocodone Tartrate (1:1), Hydrate (2:5) | Hydrocodeinonebitartrate | Hydrocon | Codinovo | Hycodan | Hycon |
|
| Chemical Information |
| Molecular Formula |
C22H27NO9 |
| CAS Registry Number |
143-71-5 |
| SMILES |
CN1CCC23C4C1CC5=C2C(=C(C=C5)OC)OC3C(=O)CC4.C(C(C(=O)O)O)(C(=O)O)O |
| Chemical Structure |
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| ADRs Induced by Drug |
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*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
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| ADR Term |
ADReCS ID |
ADR Frequency (FAERS)
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ADR Severity Grade (FAERS)
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ADR Severity Grade (CTCAE)
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| Dizziness | 17.02.05.003; 02.11.04.006; 24.06.02.007 | - | - | |
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