Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Hydroxocobalamin acetate
Drug ID BADD_D01100
Description Hydroxocobalamin, also known as vitamin B12a and hydroxycobalamin, is an injectable form of vitamin B 12 that has been used therapeutically to treat vitamin B 12 deficiency. It is also used in cyanide poisoning, Leber's optic atrophy, and toxic amblyopia.
Indications and Usage For treatment of pernicious anemia and the prevention and treatment of vitamin B12 deficiency arising from alcoholism, malabsorption, tapeworm infestation, celiac, hyperthyroidism, hepatic-biliary tract disease, persistent diarrhea, ileal resection, pancreatic cancer, renal disease, prolonged stress, vegan diets, macrobiotic diets or other restrictive diets. Also for the treatment of known or suspected cyanide poisoning.
Marketing Status approved
ATC Code B03BA03; V03AB33
DrugBank ID DB00200
KEGG ID D02707
MeSH ID D006879
PubChem ID 70689311
TTD Drug ID D0VF4H
NDC Product Code 64552-4006; 82298-920; 61281-9700; 50396-7900
UNII S535M27N3Q
Synonyms Hydroxocobalamin | Hydroxo-Cobalamin | Hydroxycobalamin
Chemical Information
Molecular Formula C62H90CoN13O15P
CAS Registry Number 13422-51-0
SMILES CC1=CC2=C(C=C1C)N(C=N2)C3C(C(C(O3)CO)OP(=O)([O-])OC(C)CNC(=O)CCC4(C(C5C6(C(C(C(= N6)C(=C7C(C(C(=N7)C=C8C(C(C(=N8)C(=C4[N-]5)C)CCC(=O)N)(C)C)CCC(=O)N)(C)CC(=O)N)C )CCC(=O)N)(C)CC(=O)N)C)CC(=O)N)C)O.O.[Co+2]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Diarrhoea07.02.01.001--
Injection site pain12.07.03.011; 08.02.03.010--Not Available
Pruritus23.03.12.001--
Rash23.03.13.001--Not Available
Sensation of foreign body08.01.09.002--Not Available
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