Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ibandronic acid
Drug ID BADD_D01117
Description Ibandronate, or BM 21.0955, is a third generation, nitrogen containing bisphosphonate similar to [zoledronic acid], [minodronic acid], and [risedronic acid].[A203111,A203138] It is used to prevent and treat postmenopausal osteoporosis.[L13805,L13808] Ibandronate was first described in the literature in 1993 as a treatment for bone loss in dogs.[A203138] Ibandronate was granted FDA approval on 16 May 2003.[L13805]
Indications and Usage For the treatment and prevention of osteoporosis in postmenopausal women.[L13805,L13808]
Marketing Status approved; investigational
ATC Code M05BA06
DrugBank ID DB00710
KEGG ID D08056
MeSH ID D000077557
PubChem ID 60852
TTD Drug ID D08SJZ
NDC Product Code Not Available
UNII UMD7G2653W
Synonyms Ibandronic Acid | Ibandronate | 1-Hydroxy-3-(methylpentylamino)propylidenebisphosphonate | (1-Hydroxy-3-(methylpentylamino)propylidene)bisphosphonate | Ibandronate Sodium Anhydrous | Boniva | Bonviva | Ibandronate Sodium | Ibandronic Acid, Sodium Salt, Monohydrate | RPR 102289A | RPR-102289A | RPR102289A | Bondronat | BM 21.0955 | BM 210955 | BM-21.0955 | BM21.0955 | BM-210955 | BM210955
Chemical Information
Molecular Formula C9H23NO7P2
CAS Registry Number 114084-78-5
SMILES CCCCCN(C)CCC(O)(P(=O)(O)O)P(=O)(O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Brain neoplasm malignant17.20.04.002; 16.30.04.0020.000317%Not Available
Exostosis of jaw15.02.04.0330.001615%Not Available
Fear of disease19.06.03.0070.000317%Not Available
Fracture delayed union12.04.02.015; 15.08.01.0020.000317%Not Available
Low turnover osteopathy15.02.03.016; 14.04.04.015; 20.01.01.0100.000634%Not Available
Exposed bone in jaw15.02.04.0340.000634%Not Available
Bone sequestrum15.02.04.0420.000317%Not Available
Hypophosphataemic osteomalacia14.04.04.018; 16.32.01.011; 15.02.03.0190.000634%Not Available
Limb mass15.03.05.0190.002154%Not Available
Surgical failure08.06.01.0490.000697%Not Available
Vulvovaginal inflammation21.14.02.014--Not Available
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