Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ifosfamide
Drug ID BADD_D01133
Description Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent.
Indications and Usage Used as a component of various chemotherapeutic regimens as third-line therapy for recurrent or refractory germ cell testicular cancer. Also used as a component of various chemotherapeutic regimens for the treatment of cervical cancer, as well as in conjunction with surgery and/or radiation therapy in the treatment of various soft tissue sarcomas. Other indications include treatment of osteosarcoma, bladder cancer, ovarian cancer. small cell lung cancer, and non-Hodgkin's lymphoma.
Marketing Status approved
ATC Code L01AA06
DrugBank ID DB01181
KEGG ID D00343
MeSH ID D007069
PubChem ID 3690
TTD Drug ID D02TLO
NDC Product Code 10019-925; 57884-0006; 63323-142; 0143-9531; 0338-3991; 15308-0411; 0338-3993; 65124-0001; 0143-9530; 10019-926; 10019-927; 10019-929
UNII UM20QQM95Y
Synonyms Ifosfamide | Isofosfamide | Isophosphamide | Iphosphamide | Iso-Endoxan | Iso Endoxan | Holoxan | NSC-109,724 | NSC 109,724 | NSC109,724 | NSC-109724 | NSC 109724 | NSC109724 | Asta Z 4942
Chemical Information
Molecular Formula C7H15Cl2N2O2P
CAS Registry Number 3778-73-2
SMILES C1CN(P(=O)(OC1)NCCCl)CCCl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Blood gonadotrophin increased13.10.03.008--Not Available
Blood oestrogen decreased13.10.05.010--Not Available
Blood pressure decreased13.14.03.002--Not Available
Body temperature increased13.15.01.001--Not Available
Bone pain15.02.01.0010.000112%
Bradycardia02.03.02.002--Not Available
Bronchospasm22.03.01.004; 10.01.03.012--
Bundle branch block left02.03.01.007--Not Available
Bundle branch block right02.03.01.011--Not Available
Capillary leak syndrome08.01.07.012; 24.06.03.001--
Cardiac arrest02.03.04.0010.000112%
Cardiac failure02.05.01.001--
Cardiogenic shock24.06.02.006; 02.05.01.003--Not Available
Cardiomyopathy02.04.01.001--Not Available
Catatonia19.11.01.001--Not Available
Cerebral infarction17.08.01.004; 24.04.06.0020.000112%Not Available
Chest pain22.12.02.003; 08.01.08.002; 02.02.02.0110.000224%Not Available
Chills15.05.03.016; 08.01.09.0010.000280%
Cholestasis09.01.01.001--Not Available
Clumsiness17.01.02.0050.000112%Not Available
Coagulopathy01.01.02.001--Not Available
Colitis07.08.01.0010.000112%
Coma17.02.09.001--Not Available
Condition aggravated08.01.03.0040.000224%Not Available
Confusional state19.13.01.001; 17.02.03.0050.000672%
Conjunctivitis11.01.06.012; 06.04.01.002--
Constipation07.02.02.001--
Cough22.02.03.001--
Cyst16.02.02.002; 08.03.05.001--Not Available
Cystitis haemorrhagic20.03.02.0030.000448%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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