Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Iloperidone
Drug ID BADD_D01134
Description Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms. Hoechst Marion Roussel Inc. researched the drug until May 1996. In June 1997 they gave the research rights to Titan Pharmaceuticals, who gave the worldwide development, manufacturing, and marketing rights to Novartis in August 1998. On June 9, 2004, Titan Pharmaceuticals gave the Phase III development rights to Vanda Pharmaceuticals. FDA approved on May 9, 2009.
Indications and Usage Treatment of acute schizophrenia.
Marketing Status approved
ATC Code N05AX14
DrugBank ID DB04946
KEGG ID D02666
MeSH ID C081732
PubChem ID 71360
TTD Drug ID D0M8VE
NDC Product Code 46016-1332; 43068-102; 51672-4178; 51672-4213; 43068-101; 43068-108; 51672-4180; 50379-0006; 63285-755; 63285-756; 66499-0067; 51672-4182; 0378-0632; 0378-0633; 43068-104; 43068-106; 43068-110; 66499-0042; 51672-4183; 0378-0631; 66022-0115; 43068-901; 51672-4181; 0378-0636; 43068-112; 43068-902; 0378-0634; 0378-0635; 43068-903; 0378-0630; 43068-113; 51672-4179; 51672-4184
UNII VPO7KJ050N
Synonyms iloperidone | Fanapt | HP 873 | HP-873 | Zomaril
Chemical Information
Molecular Formula C24H27FN2O4
CAS Registry Number 133454-47-4
SMILES CC(=O)C1=CC(=C(C=C1)OCCCN2CCC(CC2)C3=NOC4=C3C=CC(=C4)F)OC
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Salivary hypersecretion07.06.01.009--Not Available
Sedation17.02.04.0050.000287%Not Available
Seizure17.12.03.0010.000457%
Sinus congestion22.04.06.001--Not Available
Sleep apnoea syndrome22.02.01.013; 19.02.05.002; 17.15.05.001--
Somnolence19.02.05.003; 17.02.04.0060.000732%
Stomatitis07.05.06.005--
Swollen tongue07.14.02.003; 23.04.01.014; 10.01.05.0150.000418%Not Available
Syncope02.11.04.015; 24.06.02.012; 17.02.04.0080.000457%
Tachycardia02.03.02.0070.000483%Not Available
Tardive dyskinesia17.01.02.0120.000287%Not Available
Testicular pain21.13.01.005--
Thirst14.03.02.007; 08.01.09.021--Not Available
Tinnitus17.04.07.004; 04.04.01.002--
Torticollis17.01.03.003; 15.05.04.003--Not Available
Tremor17.01.06.0020.000353%
Upper respiratory tract infection11.01.13.009; 22.07.03.011--
Urethral disorder20.07.01.002--Not Available
Urinary incontinence20.02.02.010; 17.05.01.008--
Urinary retention20.02.02.011--
Urinary tract disorder20.08.01.001--Not Available
Vertigo04.04.01.003; 17.02.12.002--
Vision blurred06.02.06.007; 17.17.01.010--
Weight decreased13.15.01.005--
Weight increased13.15.01.006--
Balance disorder08.01.03.081; 17.02.02.0070.000287%Not Available
Musculoskeletal stiffness15.03.05.0270.000196%Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Walking disability26.01.01.009--Not Available
Affect lability19.04.01.001--Not Available
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ADReCS-Target
Drug Name ADR Term Target
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