Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Isosorbide
Drug ID BADD_D01209
Description Isosorbide was previously available in an oral formulation for the reduction of intraocular pressure. It was approved by the FDA in 1980, but has since been discontinued. Currently, isosorbide is an organic nitrate currently available in the [isosorbide mononitrate] and [isosorbide dinitrate] forms, and is used for the prevention of angina. Refer to these drug entries for more information.
Indications and Usage Isosorbide was previously indicated for temporary reduction of intraocular pressure and used to interrupt an acute glaucoma attack, however, this is not a currently approved indication.[L34064] Refer to [isosorbide mononitrate] and [isosorbide dinitrate] drug entries for more isosorbide indications.
Marketing Status approved; investigational
ATC Code Not Available
DrugBank ID DB09401
KEGG ID D00347
MeSH ID D007547
PubChem ID 12597
TTD Drug ID Not Available
NDC Product Code Not Available
UNII WXR179L51S
Synonyms Isosorbide | Dianhydrosorbitol
Chemical Information
Molecular Formula C6H10O4
CAS Registry Number 652-67-5
SMILES C1C(C2C(O1)C(CO2)O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Heart sounds abnormal13.14.01.002--Not Available
Hiccups22.12.01.001; 07.01.06.009--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypernatraemia14.05.04.001--
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hyperuricaemia14.09.01.003--
Hypoaesthesia23.03.03.081; 17.02.06.023--Not Available
Hypochromic anaemia01.03.02.004--Not Available
Hypokalaemia14.05.03.002--
Hypotension24.06.03.002--
Influenza like illness08.01.03.010--
Insomnia19.02.01.002; 17.15.03.002--
Intermittent claudication24.04.03.001--Not Available
Irritability08.01.03.011; 19.04.02.013--
Lethargy17.02.04.003; 08.01.01.008; 19.04.04.004--
Libido decreased21.03.02.005; 19.08.03.001--
Loss of consciousness17.02.04.004--Not Available
Lung infiltration22.01.02.004--Not Available
Malaise08.01.01.003--
Melaena07.12.02.004; 24.07.02.013--Not Available
Menopausal symptoms21.02.02.002--Not Available
Mental disability26.01.01.001--Not Available
Mental impairment19.21.02.003; 17.03.03.002--Not Available
Methaemoglobinaemia01.05.01.002--
Migraine17.14.02.001; 24.03.05.003--Not Available
Mood swings19.04.03.001--Not Available
Muscle spasms15.05.03.004--
Muscular weakness17.05.03.005; 15.05.06.001--
Musculoskeletal pain15.03.04.007--
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