Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Isosorbide dinitrate
Drug ID BADD_D01210
Description A vasodilator used in the treatment of angina pectoris. Its actions are similar to nitroglycerin but with a slower onset of action.
Indications and Usage For the prevention of angina pectoris due to coronary artery disease.
Marketing Status approved; investigational
ATC Code C01DA08; C05AE02
DrugBank ID DB00883
KEGG ID D00516
MeSH ID D007548
PubChem ID 6883
TTD Drug ID D0I1SK
NDC Product Code 0781-1635; 16714-010; 51407-148; 70771-1502; 0615-8465; 72888-084; 16714-007; 16714-008; 0143-1772; 42291-350; 55154-7991; 63629-9593; 68001-374; 68084-083; 0615-8157; 0781-1556; 43353-141; 49884-020; 49884-022; 68084-082; 70518-3444; 70518-3637; 0615-8193; 63739-367; 68001-373; 68682-193; 72888-085; 0143-1769; 0143-1771; 70518-2306; 70710-1150; 70771-1504; 70771-1505; 72888-083; 0904-6620; 0187-0192; 49884-021; 49884-556; 63739-569; 68001-375; 68682-192; 70518-0063; 70710-1148; 0615-8294; 72888-081; 46438-0634; 16714-009; 0187-0152; 49884-009; 0615-8464; 0781-1695; 0904-6619; 50268-447; 70710-1149; 70710-1151; 70771-1501; 0615-8463; 50268-448; 50268-449; 51407-147; 70518-1435; 70518-2817; 70771-1503; 72888-082; 46438-0001; 51407-149; 68001-562; 70710-1152; 43353-139; 55154-7990
UNII IA7306519N
Synonyms Isosorbide Dinitrate | Dinitrate, Isosorbide | Dilatrate | Iso-Bid | Iso Bid | IsoBid | Isodinit | Isoket | Sorbonit | Isomak R | Isordil | Isotrate | Nitrosorbide | Sorbitrate | Cardonit 40 | Isoket Retard-120 | Isoket Retard 120 | Isoket Retard120
Chemical Information
Molecular Formula C6H8N2O8
CAS Registry Number 87-33-2
SMILES C1C(C2C(O1)C(CO2)O[N+](=O)[O-])O[N+](=O)[O-]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Acute myocardial infarction24.04.04.001; 02.02.02.0010.000411%Not Available
Angina pectoris02.02.02.002; 24.04.04.0020.000411%
Angina unstable24.04.04.004; 02.02.02.004--Not Available
Asthenia08.01.01.0010.000411%Not Available
Blood pressure abnormal13.14.03.001--Not Available
Bradycardia02.03.02.002--Not Available
Cardiac failure02.05.01.0010.002669%
Dermatitis23.03.04.002--Not Available
Dermatitis exfoliative23.03.07.001; 10.01.01.004--
Dizziness02.11.04.006; 24.06.02.007; 17.02.05.0030.000903%
Drug hypersensitivity10.01.01.0010.002793%Not Available
Drug ineffective08.06.01.0060.001314%Not Available
Drug interaction08.06.03.001--Not Available
Flushing08.01.03.025; 24.03.01.002; 23.06.05.003--
Haemolytic anaemia01.06.03.002--Not Available
Headache17.14.01.0010.001396%
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypersensitivity10.01.03.0030.001396%
Hypertension24.08.02.001--
Hypotension24.06.03.0020.001930%
Loss of consciousness17.02.04.004--Not Available
Malaise08.01.01.0030.000411%
Methaemoglobinaemia01.05.01.002--
Myocardial infarction24.04.04.009; 02.02.02.0070.001109%
Myocardial ischaemia24.04.04.010; 02.02.02.0080.003573%Not Available
Nausea07.01.07.0010.001109%
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Oral discomfort07.05.05.0010.001396%Not Available
Pallor24.03.04.001; 23.03.03.031; 08.01.03.032--Not Available
Pruritus23.03.12.001--
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