Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Lansoprazole
Drug ID BADD_D01245
Description Lansoprazole marketed under the brand Prevacid, is a proton pump inhibitor (PPI) and is structurally classified as a substituted benzimidazole.[A177065] It reduces gastric acid secretion by targeting gastric H,K-ATPase pumps and is thus effective at promoting healing in ulcerative diseases, and treating gastroesophageal reflux disease (GERD) along with other pathologies caused by excessive acid secretion.[A177053]
Indications and Usage Lansoprazole is used to reduce gastric acid secretion and is approved for short term treatment of active gastric ulcers, active duodenal ulcers, erosive reflux oesophagitis, symptomatic gastroesophageal reflux disease, and non-steroidal anti-inflammatory drug (NSAID) induced gastric and duodenal ulcers. [A4892][A177065][FDA Label] It may be used in the maintenance and healing of several gastric conditions including duodenal ulcers, NSAID related gastric ulcers, and erosive esophagitis.[FDA Label] Lansoprazole prevents recurrence of gastric ulcers in patients who have a documented history of gastric ulcers who also use NSAIDs chronically. [FDA Label] Predictably, it is also useful in the management of hypersecretory conditions including Zollinger-Ellison syndrome. [FDA Label] Lansoprazole is effective at eradicating H. pylori when used in conjunction with amoxicillin and clarithromycin (triple therapy) or with amoxicillin alone (dual therapy). [FDA Label]
Marketing Status approved; investigational
ATC Code A02BC03
DrugBank ID DB00448
KEGG ID D00355
MeSH ID D064747
PubChem ID 3883
TTD Drug ID D06YYD
NDC Product Code 11532-1441; 49711-0110; 52932-0730; 53104-7526; 55111-044; 16714-185; 0113-0117; 49035-373; 50090-6154; 55111-739; 56062-283; 60687-123; 61919-655; 63629-2340; 0378-8030; 68382-543; 68382-544; 69842-755; 0536-1368; 55111-399; 65628-080; 0093-3008; 0113-0116; 41163-150; 41250-391; 62175-515; 63739-555; 63868-429; 68788-6390; 70000-0612; 71335-0043; 71335-9693; 80425-0148; 43598-109; 66332-1443; 16571-698; 36800-295; 43598-560; 45802-245; 50090-5180; 51079-121; 55111-398; 55154-0253; 55910-307; 0363-0037; 0363-1212; 64764-541; 65862-896; 67877-274; 68071-2734; 71335-1820; 71335-2078; 72189-062; 55154-4848; 61919-890; 63981-117; 0378-6981; 65841-770; 68391-117; 71335-0917; 72288-343; 82009-039; 51927-0064; 65372-1136; 16571-697; 21130-046; 30142-983; 46122-698; 51316-006; 55289-704; 68001-112; 68382-771; 70771-1132; 71335-0058; 71335-9680; 72189-279; 81522-001; 51552-1239; 51927-0262; 65977-0013; 71052-242; 75945-567; 11673-117; 11822-0016; 11822-0019; 16714-186; 0093-3009; 0093-7350; 31722-570; 0113-6117; 41250-117; 43598-161; 43598-561; 46122-107; 60760-544; 64764-046; 68071-2274; 68071-5119; 70000-0069; 71335-1521; 71335-9694; 80425-0174; 0378-3995; 38779-2289; 42765-023; 63850-3309; 64374-007; 65015-658; 66332-1442; 0113-6002; 0113-7116; 41520-816; 49035-411; 50090-6079; 0363-0739; 0378-8015; 65862-895; 68001-111; 68196-045; 71335-0575; 71335-1425; 16571-742; 0093-7351; 30142-192; 51407-324; 0363-1419; 64764-543; 65841-769; 68016-758; 68382-772; 69256-401; 69842-270; 70700-262; 70756-806; 70756-807; 70771-1133; 72288-301; 83324-001; 63415-0060; 11673-280; 11822-3374; 31722-571; 0113-7003; 41163-117; 45865-879; 49348-301; 56062-117; 60687-111; 62011-0168; 63187-152; 63629-4851; 63981-582; 69842-507; 79903-068; 11532-1440; 21130-564; 27241-019; 27241-020; 30142-288; 45802-878; 63187-510; 0363-4069; 63629-2341; 63629-2342; 64764-544; 0378-6982; 67877-275; 68788-7742; 70000-0508; 70677-0124; 0536-1324; 70700-263; 71335-9695; 72288-829; 72476-020; 0904-6662; 51927-0256; 52562-021; 59349-0015; 11822-0117; 21130-181; 30142-117; 0113-1114; 36800-117; 36800-392; 37808-755; 43598-883; 49035-739; 55910-117
UNII 0K5C5T2QPG
Synonyms Lansoprazole | Lansoprazol | 2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl)methyl)sulfinyl)benzimidazole | Lansoprazoles | Ogastro | AG 1749 | AG-1749 | AG1749 | Agopton | Bamalite | Lansol | Lansoprazole Sodium | Sodium, Lansoprazole | Lanzor | Monolitum | Opiren | Prevacid | Pro Ulco | Promeco | Takepron | Ulpax | Zoton | Ogast | Prezal
Chemical Information
Molecular Formula C16H14F3N3O2S
CAS Registry Number 103577-45-3
SMILES CC1=C(C=CN=C1CS(=O)C2=NC3=CC=CC=C3N2)OCC(F)(F)F
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Blood disorder01.05.01.0040.000149%Not Available
Gastrointestinal malformation07.11.04.004; 03.04.07.002--Not Available
Blood electrolytes decreased13.11.02.007--Not Available
Blood electrolytes increased13.11.02.008--Not Available
Disease recurrence08.01.03.0500.000318%Not Available
Drug intolerance08.06.01.013--Not Available
Diabetic nephropathy20.05.03.011; 14.07.02.003; 05.07.02.0030.000249%Not Available
Occult blood positive13.05.02.001--Not Available
Gastric neoplasm16.13.11.003; 07.21.04.0060.000149%Not Available
Hyperlipidaemia14.08.03.001--
Renal mass20.01.02.0070.000149%Not Available
Urine analysis abnormal13.13.02.008--Not Available
Renal impairment20.01.03.0100.001144%Not Available
Congenital genitourinary abnormality21.15.02.002; 20.08.03.001; 03.06.02.002--Not Available
Gastrointestinal inflammation07.08.03.007--Not Available
Osteonecrosis of jaw15.02.04.010; 24.04.05.0050.000199%
Infusion site extravasation12.07.05.008; 08.02.05.0070.000099%
Chronic kidney disease20.01.03.0170.007657%
Aortic arteriosclerosis24.04.01.004--Not Available
Substance abuse19.07.06.0180.000099%Not Available
Cytopenia01.03.03.0120.000099%Not Available
Mixed liver injury09.01.07.0150.000099%Not Available
Liver injury12.01.17.012; 09.01.07.0220.000199%Not Available
Regurgitation07.01.07.0040.000656%Not Available
Adverse reaction08.06.01.018--Not Available
Renal cell carcinoma20.01.04.003; 16.08.02.0020.000099%Not Available
Cholestatic liver injury09.01.07.0160.000348%Not Available
Anal pruritus07.03.03.002--Not Available
Hypertransaminasaemia09.01.02.0050.000099%Not Available
Anorectal discomfort07.03.03.003--Not Available
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ADReCS-Target
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