Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Laronidase
Drug ID BADD_D01249
Description Human recombinant alpha-L-iduronidase, 628 residues (mature form), produced by recombinant DNAtechnology in a Chinese hamster ovary cell line. Laronidase is a glycoprotein with a molecular weight of approximately 83 kD. The predicted amino acid sequence of the recombinant form, as well as the nucleotide sequence that encodes it, are identical to a polymorphic form of human a-L-iduronidase. It contains 6 N-linked oligosaccharide modification sites.
Indications and Usage For the treatment of mucopolysaccharidosis
Marketing Status approved
ATC Code A16AB05
DrugBank ID DB00090
KEGG ID D04670
MeSH ID Not Available
PubChem ID Not Available
TTD Drug ID D03LUN
NDC Product Code 68135-000; 58468-0070
UNII WP58SVM6R4
Synonyms Not Available
Chemical Information
Molecular Formula Not Available
CAS Registry Number 210589-09-6
SMILES Not Available
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Injection site pain12.07.03.011; 08.02.03.010--Not Available
Injection site reaction12.07.03.015; 08.02.03.014--
Musculoskeletal pain15.03.04.007--
Nausea07.01.07.001--
Otitis media11.01.05.004; 04.05.01.001--
Oxygen saturation decreased13.02.01.004--Not Available
Pallor24.03.04.001; 23.03.03.031; 08.01.03.032--Not Available
Paraesthesia23.03.03.094; 17.02.06.005--
Pneumonia22.07.01.003; 11.01.09.003--Not Available
Pruritus23.03.12.001--
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Respiratory distress22.02.01.012--Not Available
Respiratory failure14.01.04.003; 22.02.06.002--
Tachycardia02.03.02.007--Not Available
Thrombocytopenia01.08.01.002--Not Available
Tremor17.01.06.002--
Upper respiratory tract infection22.07.03.011; 11.01.13.009--
Urticaria23.04.02.001; 10.01.06.001--
Vomiting07.01.07.003--
Wheezing22.03.01.009--
Poor venous access24.03.02.017--Not Available
Infusion related reaction12.02.05.009; 10.01.01.017; 08.01.03.002--
Central venous catheterisation25.03.02.001--Not Available
Antibody test13.06.03.009--Not Available
Infestation23.11.01.002; 11.09.01.001--Not Available
Antibody test positive13.06.03.001--Not Available
Obstructive airways disorder22.03.01.011--Not Available
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