ADReCS

Pharmaceutical Information

Drug Name	Latanoprost
Drug ID	BADD_D01251
Description	Latanoprost is a prodrug analog of prostaglandin F2 alpha that is used to treat elevated intraocular pressure (IOP). It was initially approved by the FDA in 1998. Latanoprost is the first topical prostaglandin F2 alpha analog used for glaucoma treatment.[A184493] It has been found to be well-tolerated and its use does not normally result in systemic adverse effects like other drugs used to treat elevated intraocular pressure, such as [Timolol]. Another benefit latanoprost is that it can be administered once a day.[A184490]
Indications and Usage	Latanoprost is indicated for the reduction of elevated intraocular pressure in patients who have been diagnosed with open-angle glaucoma or ocular hypertension.[L8357] Latanoprost may be combined in a product with [Netarsudil], a rho kinase inhibitor, for the same indications.[L8369] In addition to the above indications, the Canadian monograph for this drug also approves latanoprost for the treatment of elevated intraocular pressure as a result of angle-closure glaucoma that has been treated with peripheral iridotomy or laser iridoplasty.[L8366]
Marketing Status	approved; investigational
ATC Code	S01EE01
DrugBank ID	DB00654
KEGG ID	D00356
MeSH ID	D000077338
PubChem ID	5311221
TTD Drug ID	D0C6NM
NDC Product Code	65727-026; 82187-1002; 71205-154; 62991-3186; 65427-007; 82231-111; 50090-1920; 59762-0333; 54893-0010; 63190-0710; 65326-004; 61314-547; 65862-872; 0009-5172; 12079-0475; 42385-039; 51552-1385; 51927-4864; 68245-0002; 81997-001; 10695-048; 90027-006; 47335-317; 70069-421; 65035-128; 71684-0547; 73212-027; 55545-0462; 71052-041; 24208-463; 64980-516; 68071-4612; 40016-001; 61556-050; 0013-8303; 24002-0018; 73377-237
UNII	6Z5B6HVF6O
Synonyms	Latanoprost \| PhXA34 \| PHXA41 \| Xalatan

Chemical Information

Molecular Formula	C26H40O5
CAS Registry Number	130209-82-4
SMILES	CC(C)OC(=O)CCCC=CCC1C(CC(C1CCC(CCC2=CC=CC=C2)O)O)O
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Abnormal sensation in eye	06.01.01.001	0.000144%		Not Available
Abortion missed	18.01.01.002	0.000067%		Not Available
Acne	23.02.01.001	0.000121%		Not Available
Ageusia	17.02.07.001; 07.14.03.003	0.000175%		Not Available
Angina pectoris	24.04.04.002; 02.02.02.002	0.000045%
Anosmia	22.04.03.006; 17.04.04.001	0.000342%
Application site erythema	08.02.01.001; 23.03.06.005; 12.07.01.001	-	-	Not Available
Application site irritation	12.07.01.003; 08.02.01.003	-	-	Not Available
Application site pain	12.07.01.004; 08.02.01.004	0.000045%		Not Available
Arrhythmia	02.03.02.001	0.000247%		Not Available
Arthralgia	15.01.02.001	-	-
Arthritis	15.01.01.001	0.000810%
Arthropathy	15.01.01.003	0.000310%		Not Available
Asthenopia	06.01.01.002	0.000045%		Not Available
Asthma	22.03.01.002; 10.01.03.010	0.000301%		Not Available
Atrial tachycardia	02.03.03.004	0.000112%
Atrioventricular block second degree	02.03.01.005	0.000090%
Back disorder	15.03.05.003	0.000099%		Not Available
Back pain	15.03.04.005	-	-
Blepharal pigmentation	23.05.01.009; 06.06.04.014	0.000045%		Not Available
Blepharitis	23.03.04.012; 06.04.04.001	0.000175%		Not Available
Blindness	06.02.10.003; 17.17.01.003	0.000427%		Not Available
Blindness unilateral	06.02.10.007; 17.17.01.016	0.000202%		Not Available
Blister	12.01.06.002; 23.03.01.001	0.000328%		Not Available
Blood pressure fluctuation	24.06.01.002	0.000045%		Not Available
Bradycardia	02.03.02.002	0.000247%		Not Available
Bronchitis	22.07.01.001; 11.01.09.001	-	-
Bronchospasm	10.01.03.012; 22.03.01.004	0.000090%
Burning sensation	17.02.06.001; 08.01.09.029	0.000679%		Not Available
Cataract	06.06.01.001	0.001462%

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