Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Levocarnitine
Drug ID BADD_D01271
Description Constituent of striated muscle and liver. It is used therapeutically to stimulate gastric and pancreatic secretions and in the treatment of hyperlipoproteinemias.
Indications and Usage For treatment of primary systemic carnitine deficiency, a genetic impairment of normal biosynthesis or utilization of levocarnitine from dietary sources, or for the treatment of secondary carnitine deficiency resulting from an inborn error of metabolism such as glutaric aciduria II, methyl malonic aciduria, propionic acidemia, and medium chain fatty acylCoA dehydrogenase deficiency. Used therapeutically to stimulate gastric and pancreatic secretions and in the treatment of hyperlipoproteinemias. Parenteral levocarnitine is indicated for the prevention and treatment of carnitine deficiency in patients with end-stage renal disease.
Marketing Status approved; investigational
ATC Code A16AA01
DrugBank ID DB00583
KEGG ID D02176
MeSH ID D002331
PubChem ID 10917
TTD Drug ID D0G8SQ
NDC Product Code 81999-0005; 50383-171; 50383-172; 54482-147; 54482-148; 54482-145; 54482-144; 0143-9852; 52817-830; 58116-010; 59380-018; 64980-503; 0517-1045; 51927-0240; 70954-492; 49452-1778; 51927-1865; 16571-762; 58159-089; 42765-049; 76055-1005
UNII 0G389FZZ9M
Synonyms Carnitine | Levocarnitine | Vitamin BT | L-Carnitine | L Carnitine | Bicarnesine
Chemical Information
Molecular Formula C7H15NO3
CAS Registry Number 541-15-1
SMILES C[N+](C)(C)CC(CC(=O)[O-])O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pharyngitis22.07.03.004; 11.01.13.003; 07.05.07.004--
Pruritus23.03.12.001--
Rash23.03.13.001--Not Available
Renal failure20.01.03.005--Not Available
Restlessness19.11.02.002; 17.02.05.0210.004312%
Rhabdomyolysis15.05.05.0020.008625%
Rhinitis22.07.03.006; 11.01.13.004--
Seizure17.12.03.0010.014662%
Sinusitis22.07.03.007; 11.01.13.005--
Skin odour abnormal23.03.03.012--
Tachycardia02.03.02.007--Not Available
Urinary tract infection20.08.02.001; 11.01.14.004--
Vertigo17.02.12.002; 04.04.01.003--
Vomiting07.01.07.0030.009487%
Weight decreased13.15.01.005--
Weight increased13.15.01.006--
Musculoskeletal discomfort15.03.04.001--Not Available
Haemorrhage24.07.01.002--Not Available
Angiopathy24.03.02.007--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Hypophagia14.03.01.006; 07.01.06.010; 19.09.01.0040.004312%Not Available
Posterior reversible encephalopathy syndrome17.13.02.0070.004312%
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